Prevalence and clinical correlates of ascending aortic dilatation in patients with noncompaction cardiomyopathy

Ascending aortic (AoAsc) dilatation can lead to acute aortic syndromes and has been described in various familial cardiac diseases. Its prevalence and clinical significance in patients with noncompaction cardiomyopathy (NCCM) are however unknown. Establishing the prevalence can facilitate recommenda...

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Bibliographic Details
Published in:The international journal of cardiovascular imaging 2023-09, Vol.39 (9), p.1687-1695
Main Authors: Tukker, Martijn, Leening, Maarten J.G., Mohamedhoesein, Sharida, Vanmaele, Alexander L.A., Caliskan, Kadir
Format: Article
Language:English
Subjects:
Aorta
Cardiac Imaging
Cardiology
Cardiomyopathy
Cohort analysis
Congestive heart failure
Coronary artery disease
Cross-sectional studies
Diameters
Dilated cardiomyopathy
Genetic diversity
Genetic variance
Heart diseases
Heart failure
Imaging
Medicine
Medicine & Public Health
Original Paper
Radiology
Sex
Sinuses
Ventricle
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Summary:Ascending aortic (AoAsc) dilatation can lead to acute aortic syndromes and has been described in various familial cardiac diseases. Its prevalence and clinical significance in patients with noncompaction cardiomyopathy (NCCM) are however unknown. Establishing the prevalence can facilitate recommendations on routine screening in NCCM. In this cross-sectional cohort study based on the Rijnmond Heart Failure/Cardiomyopathy Registry, the patient were enrolment between 2014 and 2021. All NCCM patients (n = 109) were age and sex matched with 109 dilated cardiomyopathy (DCM) patients as controls. The aortic diameters were measured through the parasternal long-axis transthoracic echocardiographic view at the sinuses of valsalva (SoV-Ao), sinotubular junction (STJ) and ascending aorta (AscAo). Dilatation was defined using published criteria adjusted for body surface area (BSA), sex, and age. Median age of age-sex matched NCCM and DCM patients was 45[31–56] vs. 45 [31–55] years with 53% males in both groups. NCCM patients had more familial hereditary patterns and genetic variants (55% vs. 24%, p 
ISSN:1875-8312
1569-5794
1875-8312
1573-0743
DOI:10.1007/s10554-023-02882-2