Neutrophil biology in injuries and diseases of the central and peripheral nervous systems

• Published in: Progress in neurobiology 2023-09, Vol.228, p.102488-102488, Article 102488
• Main Authors: Balog, Brian M., Sonti, Anisha, Zigmond, Richard E.
• Format: Article
• Language: English
• Subjects: Axons - physiology; Biology; Chemokine; Humans; Nerve injury; Nerve Regeneration - physiology; Neutrophil; Neutrophil extracellular trap; Neutrophils; Peripheral Nervous System; Phagocytosis; Polymorphonuclear leukocyte; Wallerian degeneration
• ISSN: 0301-0082; 1873-5118; 1873-5118
• DOI: 10.1016/j.pneurobio.2023.102488

The role of inflammation in nervous system injury and disease is attracting increased attention. Much of that research has focused on microglia in the central nervous system (CNS) and macrophages in the peripheral nervous system (PNS). Much less attention has been paid to the roles played by neutrophils. Neutrophils are part of the granulocyte subtype of myeloid cells. These cells, like macrophages, originate and differentiate in the bone marrow from which they enter the circulation. After tissue damage or infection, neutrophils are the first immune cells to infiltrate into tissues and are directed there by specific chemokines, which act on chemokine receptors on neutrophils. We have reviewed here the basic biology of these cells, including their differentiation, the types of granules they contain, the chemokines that act on them, the subpopulations of neutrophils that exist, and their functions. We also discuss tools available for identification and further study of neutrophils. We then turn to a review of what is known about the role of neutrophils in CNS and PNS diseases and injury, including stroke, Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, spinal cord and traumatic brain injuries, CNS and PNS axon regeneration, and neuropathic pain. While in the past studies have focused on neutrophils deleterious effects, we will highlight new findings about their benefits. Studies on their actions should lead to identification of ways to modify neutrophil effects to improve health. •Our understanding of neutrophil’s role in the nervous system has advanced.•Subpopulations of neutrophils have been found and may have unique roles.•Neutrophil extracellular traps are found in neurological conditions.•Neutrophils play a role in neuropathic pain, although the literature are mixed.•Neutrophils are involved in Wallerian degeneration.