Characteristics of type 1 diabetes mellitus in children and adolescents with Down's syndrome in an admixed population

ABSTRACT Objective: People with Down's syndrome (DS) have a higher risk of developing type 1 diabetes mellitus (T1D) and may have specific clinical features compared to T1D patients without DS. This study evaluated the clinical and laboratory aspects of T1D in children and adolescents with DS i...

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Published in:Archives of Endocrinology and Metabolism 2021-10, Vol.65 (5), p.562-569
Main Authors: Pessoa, Débora Martins Ferreira, Oliveira, Nara Lívia Rezende Soares da Paz, Dantas, Giuliane de Santana, Fernandes, Vania de Fátima Tonetto, Noronha, Renata Maria de, Calliari, Luis Eduardo
Format: Article
Language:English
Subjects:
adolescent
autoimmunity
child
diabetes mellitus type 1
Down syndrome
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Summary:ABSTRACT Objective: People with Down's syndrome (DS) have a higher risk of developing type 1 diabetes mellitus (T1D) and may have specific clinical features compared to T1D patients without DS. This study evaluated the clinical and laboratory aspects of T1D in children and adolescents with DS in an admixed population. Subjects and methods: A case-control study comparing patients with T1D and DS (T1D+DS) to patients with T1D without DS (T1D controls) from two tertiary academic Hospitals in São Paulo, Brazil. Results: The sample consisted of 9 patients with T1D+DS and 18 T1D age and sex-matched controls. Anti-glutamic acid decarboxylase 65 antibodies were positive in 7/7 of the 9 T1D+DS patients, confirming the presence of diabetes autoimmunity in this group. Mean age at diagnosis of T1D was 4.9 ± 3.9 years in the T1D+DS group and 6.4 years ± 3 in the T1D control group; early diagnosis (
ISSN:2359-3997
2359-4292
DOI:10.20945/2359-3997000000365