Difference between remimazolam toluenesulfonic acid and propofol in waking quality and conscious state after general anesthesia

• Published in: Ibrain 2021-09, Vol.7 (3), p.171-180
• Main Authors: Li, Juan, Zhou, Di, Jin, Yang, Zhou, Hong‐Su, Fang, Chang‐Le, Zhu, Zhao‐Qiong, Xiong, Liu‐Lin
• Format: Article
• Language: English
• Subjects: Original; Propofol; Recovery quality; Remimazolam Toluenesulfonic acid; State of consciousness
• ISSN: 2769-2795; 2313-1934; 2769-2795
• DOI: 10.1002/j.2769-2795.2021.tb00081.x

Objective To explore the difference of anesthesia recovery and postoperative conscious state between remimazolam toluenesulfonic acid and propofol after induction and maintenance of general anesthesia. Methods 104 patients undergoing elective tracheal intubation general anesthesia in our hospital were randomly divided into 2 groups: Remimazolam Toluenesulfonic acid group (Group R) and Propofol group (Group P). MOAA/S score, the modified Aldrete score, recovery index, time point, a state of consciousness, interpretative vital signs and adverse events were monitored at different time. Results Compared with the Group P, the extubation time and orientation recovery time of the Group R were significantly shorter. When the operation time was less than 1 hour, the MOAA/S score of the Group R was shorter than that of Group P at 5 min and 15 min after the operation. To compare with the Group P, the score of MOAA/S in the Group R increased at 5 min, 20 min and 30 min after the operation. When the operation time was less than or equal to 1 h, the modified Aldrete score in the Group R was slightly higher than that in the Group P at 30 min after extubation. There was no injection pain in the the Group R, and the incidence of hypotension was lower than that of propofol. Conclusion Compared with Propofol, when the operation time of general anesthesia is more than 1 hour, recovery time of Remimazolam Toluenesulfonic acid is shorter, with more complete and higher‐quality recovery.