Unraveling the Intricate Link: Deciphering the Role of the Golgi Apparatus in Breast Cancer Progression

Breast cancer represents a paramount global health challenge, warranting intensified exploration of the molecular underpinnings influencing its progression to facilitate the development of precise diagnostic instruments and customized therapeutic regimens. Historically, the Golgi apparatus has been...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-09, Vol.24 (18), p.14073
Main Authors: Dumitru, Adrian Vasile, Stoica, Evelina-Elena, Covache-Busuioc, Razvan-Adrian, Bratu, Bogdan-Gabriel, Cirstoiu, Monica-Mihaela
Format: Article
Language:English
Subjects:
Analysis
Angiogenesis
Apoptosis
Architecture
Breast cancer
Cell adhesion & migration
Deoxyribonucleic acid
Development and progression
DNA
Enzymes
Health aspects
Medical research
Medicine, Experimental
Metabolism
Metastasis
Motility
Pertuzumab
Proteins
Review
Signal transduction
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Summary:Breast cancer represents a paramount global health challenge, warranting intensified exploration of the molecular underpinnings influencing its progression to facilitate the development of precise diagnostic instruments and customized therapeutic regimens. Historically, the Golgi apparatus has been acknowledged for its primary role in protein sorting and trafficking within cellular contexts. However, recent findings suggest a potential link between modifications in Golgi apparatus function and organization and the pathogenesis of breast cancer. This review delivers an exhaustive analysis of this correlation. Specifically, we examine the consequences of disrupted protein glycosylation, compromised protein transport, and inappropriate oncoprotein processing on breast cancer cell dynamics. Furthermore, we delve into the impacts of Golgi-mediated secretory routes on the release of pro-tumorigenic factors during the course of breast cancer evolution. Elucidating the nuanced interplay between the Golgi apparatus and breast cancer can pave the way for innovative therapeutic interventions and the discovery of biomarkers, potentially enhancing the diagnostic, prognostic, and therapeutic paradigms for afflicted patients. The advancement of such research could substantially expedite the realization of these objectives.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241814073