Exploring the Potential of Proteome Analysis as a Promising Tool for Evaluation of Sudden Cardiac Death (SCD) in Forensic Settings: A Literature Review

Sudden cardiac death (SCD) represents a global emergency, with a high number of cases affecting all age groups every year. The prevention of these fatal events requires an accurate knowledge of etiology and pathogenesis, which can vary. Autopsy is an indispensable tool in cases of SCD for diagnostic...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-09, Vol.24 (18), p.14351
Main Authors: Sacco, Matteo Antonio, Gualtieri, Saverio, Calanna, Luca, Ricci, Pietrantonio, Aquila, Isabella
Format: Article
Language:English
Subjects:
Atherosclerosis
Autopsies
Cadavers
Cardiac arrest
Cardiomyopathy
Cardiovascular disease
Coronary vessels
Diagnosis
Disease prevention
Epidemiology
Heart
Heart failure
Hypertension
Ischemia
Lifesaving
Literature reviews
Peptides
Proteins
Proteomics
Review
Scientific imaging
Vein & artery diseases
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Summary:Sudden cardiac death (SCD) represents a global emergency, with a high number of cases affecting all age groups every year. The prevention of these fatal events requires an accurate knowledge of etiology and pathogenesis, which can vary. Autopsy is an indispensable tool in cases of SCD for diagnostic purposes, as well as for judicial and preventive purposes for family members. Despite the completion of all routine post-mortem investigations, it is often complicated for the forensic pathologist to define the triggering cause of these events. The study of the proteome is proving to be extremely promising in the field of human cardiovascular disease. This paper aims to offer a literature review on the study of the proteome in post-mortem cadaveric biological samples obtained from SCD cases. The aim of this work is to outline the state of the art of the scientific advances that protein analysis can offer in the diagnosis of SCD and the limits that various studies have traced up to now. In conclusion, the work defines the future perspectives of this field in SCD, suggesting strategies to overcome the reported limits and improve the diagnostics of these events.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241814351