The antimicrobial peptide MetchnikowinII enhances Ptfa antigen immune responses against avian Pasteurella multocida in chickens

Immunostimulants and vaccines are the main means for controlling infectious diseases and searching highly effective and low toxic immunestimulants has always been the focus of researchers. The MetchnikowinII (MetII) had been expressed by us and exhibited both antibacterial and antifungal activities,...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2023, Vol.85(9), pp.964-971
Main Authors: MINGFU, Niu, QIANG, Gong, YANG, Li, YING, Hou, CHENGSHUI, Liao, CUILI, Qin
Format: Article
Language:English
Subjects:
Adjuvants
Antigens
antimicrobial peptide MetchnikowinII
Antimicrobial peptides
immune adjuvant
immune effect
Immune response
Immunology
Immunostimulants
Infectious diseases
Interleukin 2
Pasteurella multocida
Peptides
Poultry
Propolis
subunit vaccines
Vaccines
γ-Interferon
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Summary:Immunostimulants and vaccines are the main means for controlling infectious diseases and searching highly effective and low toxic immunestimulants has always been the focus of researchers. The MetchnikowinII (MetII) had been expressed by us and exhibited both antibacterial and antifungal activities, in this study, we evaluated its potential for an adjuvant effect. In chickens, antigen-specific immunoglobulin Gs (IgGs) were increased after MetII adjuvanted vaccination using the Ptfa protein. Compared to group Ptfa + iFA, which was only adjuvanted with incomplete Freund’s adjuvant (iFA), the antibody titers of the group Ptfa + iFA + Met20 μg·mL−1 (PFM20) and Ptfa + iFA + Propolis (PFP) significantly increased (P
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.22-0579