Identifying the causal relationship between sedentary behavior and heart failure: Insights from a Mendelian randomization study and mediation analysis

BackgroundObservational studies have revealed that a lack of physical exercise may be linked to a higher risk of heart failure (HF). Here, the causal relationship between sedentary behavior (SB) and HF was investigated using Mendelian randomization (MR).HypothesisSB was considered as an important ri...

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Bibliographic Details
Published in:Clinical cardiology (Mahwah, N.J.) N.J.), 2023-09, Vol.46 (9), p.1082-1089
Main Authors: Zheng, Xifeng, Liu, Manqi, Wu, Zijun, Jia, Zhen
Format: Article
Language:English
Subjects:
Behavior
Biobanks
Body mass index
Cardiac arrhythmia
Cardiovascular disease
Clinical Investigations
Coronary vessels
Coronaviruses
Datasets
Diabetes
Energy consumption
Epidemiology
Genomes
Heart failure
Hypertension
Metabolism
Mortality
Obesity
Pulmonary embolisms
Quality of life
Screen time
Sedentary behavior
Sensitivity analysis
Variables
Vein & artery diseases
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Summary:BackgroundObservational studies have revealed that a lack of physical exercise may be linked to a higher risk of heart failure (HF). Here, the causal relationship between sedentary behavior (SB) and HF was investigated using Mendelian randomization (MR).HypothesisSB was considered as an important risk factor of HF.MethodsSingle nucleotide polymorphisms with a genome-wide statistical significance threshold of
ISSN:0160-9289
1932-8737
DOI:10.1002/clc.24101