Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development

Abstract The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development, held virtually on 7–8 June 2022, provided comprehensive coverage of critical concepts intended to help scientists establish robust, repro...

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Bibliographic Details
Published in:The Journal of infectious diseases 2023-10, Vol.228 (Supplement_5), p.S337-S354
Main Authors: Jordan, Robert, Ford-Scheimer, Stephanie L, Alarcon, Rodolfo M, Atala, Anthony, Borenstein, Jeffrey T, Brimacombe, Kyle R, Cherry, Sara, Clevers, Hans, Davis, Mindy I, Funnell, Simon G P, Gehrke, Lee, Griffith, Linda G, Grossman, Abigail C, Hartung, Thomas, Ingber, Donald E, Kleinstreuer, Nicole C, Kuo, Calvin J, Lee, Emily M, Mummery, Christine L, Pickett, Thames E, Ramani, Sasirekha, Rosado-Olivieri, Edwin A, Struble, Evi B, Wan, Zhengpeng, Williams, Mark S, Hall, Matthew D, Ferrer, Marc, Markossian, Sarine
Format: Article
Language:English
Subjects:
3-D technology
Antiviral drugs
Drug development
Infectious diseases
Supplement
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Summary:Abstract The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development, held virtually on 7–8 June 2022, provided comprehensive coverage of critical concepts intended to help scientists establish robust, reproducible, and scalable 3D tissue models to study viruses with pandemic potential. This workshop was organized by NCATS, the National Institute of Allergy and Infectious Diseases, and the Bill and Melinda Gates Foundation. During the workshop, scientific experts from academia, industry, and government provided an overview of 3D tissue models’ utility and limitations, use of existing 3D tissue models for antiviral drug development, practical advice, best practices, and case studies about the application of available 3D tissue models to infectious disease modeling. This report includes a summary of each workshop session as well as a discussion of perspectives and challenges related to the use of 3D tissues in antiviral drug discovery.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiad334