Improved Thermal Sensitivity Using Virtual Monochromatic Imaging Derived from Photon Counting Detector CT Data Sets: Ex Vivo Results of CT-Guided Cryoablation in Porcine Liver

Purpose To investigate differences in thermal sensitivity of virtual monoenergetic imaging (VMI) series generated from photon-counting detector (PCD) CT data sets, regarding their use to improve discrimination of the ablation zone during percutaneous cryoablation. Materials and Methods CT-guided cry...

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Bibliographic Details
Published in:Cardiovascular and interventional radiology 2023-10, Vol.46 (10), p.1385-1393
Main Authors: Decker, Josua A., Risch, Franka, Schwarz, Florian, Scheurig-Muenkler, Christian, Kroencke, Thomas J.
Format: Article
Language:English
Subjects:
Ablation
Cardiology
Computed tomography
Datasets
Heat detection
Imaging
Laboratory Investigation
Liver
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Photons
Probes
Radiology
Sensitivity
Temperature probes
Ultrasound
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Summary:Purpose To investigate differences in thermal sensitivity of virtual monoenergetic imaging (VMI) series generated from photon-counting detector (PCD) CT data sets, regarding their use to improve discrimination of the ablation zone during percutaneous cryoablation. Materials and Methods CT-guided cryoablation was performed using an ex vivo model of porcine liver on a PCD-CT system. The ablation zone was imaged continuously for 8 min by acquiring a CT scan every 5 s. Tissue temperature was measured using fiberoptic temperature probes placed parallel to the cryoprobe. CT-values and noise were measured at the tip of the temperature probes on each scan and on VMI series from 40 to 130 keV. Correlation of CT-values and temperature was assessed using linear regression analyses. Results For the whole temperature range of [− 40, + 20] °C, we observed a linear correlation between CT-values and temperature in reference 70 keV images ( R 2  = 0.60, p  
ISSN:0174-1551
1432-086X
DOI:10.1007/s00270-023-03546-3