Improved Thermal Sensitivity Using Virtual Monochromatic Imaging Derived from Photon Counting Detector CT Data Sets: Ex Vivo Results of CT-Guided Cryoablation in Porcine Liver

Purpose To investigate differences in thermal sensitivity of virtual monoenergetic imaging (VMI) series generated from photon-counting detector (PCD) CT data sets, regarding their use to improve discrimination of the ablation zone during percutaneous cryoablation. Materials and Methods CT-guided cry...

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Published in:Cardiovascular and interventional radiology 2023-10, Vol.46 (10), p.1385-1393
Main Authors: Decker, Josua A., Risch, Franka, Schwarz, Florian, Scheurig-Muenkler, Christian, Kroencke, Thomas J.
Format: Article
Language:English
Subjects:
Ablation
Cardiology
Computed tomography
Datasets
Heat detection
Imaging
Laboratory Investigation
Liver
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Photons
Probes
Radiology
Sensitivity
Temperature probes
Ultrasound
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container_title Cardiovascular and interventional radiology
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creator Decker, Josua A.
Risch, Franka
Schwarz, Florian
Scheurig-Muenkler, Christian
Kroencke, Thomas J.
description Purpose To investigate differences in thermal sensitivity of virtual monoenergetic imaging (VMI) series generated from photon-counting detector (PCD) CT data sets, regarding their use to improve discrimination of the ablation zone during percutaneous cryoablation. Materials and Methods CT-guided cryoablation was performed using an ex vivo model of porcine liver on a PCD-CT system. The ablation zone was imaged continuously for 8 min by acquiring a CT scan every 5 s. Tissue temperature was measured using fiberoptic temperature probes placed parallel to the cryoprobe. CT-values and noise were measured at the tip of the temperature probes on each scan and on VMI series from 40 to 130 keV. Correlation of CT-values and temperature was assessed using linear regression analyses. Results For the whole temperature range of [− 40, + 20] °C, we observed a linear correlation between CT-values and temperature in reference 70 keV images ( R 2  = 0.60, p  
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Materials and Methods CT-guided cryoablation was performed using an ex vivo model of porcine liver on a PCD-CT system. The ablation zone was imaged continuously for 8 min by acquiring a CT scan every 5 s. Tissue temperature was measured using fiberoptic temperature probes placed parallel to the cryoprobe. CT-values and noise were measured at the tip of the temperature probes on each scan and on VMI series from 40 to 130 keV. Correlation of CT-values and temperature was assessed using linear regression analyses. Results For the whole temperature range of [− 40, + 20] °C, we observed a linear correlation between CT-values and temperature in reference 70 keV images ( R 2  = 0.60, p  &lt; 0.001) with a thermal sensitivity of 1.4 HU / °C . For the most dynamic range of [− 15, + 20] °C, the sensitivity increased to 2.4 HU / °C ( R 2  = 0.50, p  &lt; 0.001). Using VMI reconstructions, the thermal sensitivity increased from 1.4  HU / °C at 70 keV to 1.5, 1.7 and 2.0 HU / °C at 60, 50 and 40 keV, respectively (range [− 40, + 20] °C). For [− 15, + 20]°C, the thermal sensitivity increased from 2.4 HU / °C at 70 keV to 2.5, 2.6 and 2.7 HU / °C at 60, 50 and 40 keV, respectively. Both CT-values and noise also increased with decreasing VMI keV-levels. Conclusion During CT-guided cryoablation of porcine liver, low-keV VMI reconstructions derived from PCD-CT data sets exhibit improved thermal sensitivity being highest between + 20 and − 15 °C. 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Materials and Methods CT-guided cryoablation was performed using an ex vivo model of porcine liver on a PCD-CT system. The ablation zone was imaged continuously for 8 min by acquiring a CT scan every 5 s. Tissue temperature was measured using fiberoptic temperature probes placed parallel to the cryoprobe. CT-values and noise were measured at the tip of the temperature probes on each scan and on VMI series from 40 to 130 keV. Correlation of CT-values and temperature was assessed using linear regression analyses. Results For the whole temperature range of [− 40, + 20] °C, we observed a linear correlation between CT-values and temperature in reference 70 keV images ( R 2  = 0.60, p  &lt; 0.001) with a thermal sensitivity of 1.4 HU / °C . For the most dynamic range of [− 15, + 20] °C, the sensitivity increased to 2.4 HU / °C ( R 2  = 0.50, p  &lt; 0.001). Using VMI reconstructions, the thermal sensitivity increased from 1.4  HU / °C at 70 keV to 1.5, 1.7 and 2.0 HU / °C at 60, 50 and 40 keV, respectively (range [− 40, + 20] °C). For [− 15, + 20]°C, the thermal sensitivity increased from 2.4 HU / °C at 70 keV to 2.5, 2.6 and 2.7 HU / °C at 60, 50 and 40 keV, respectively. Both CT-values and noise also increased with decreasing VMI keV-levels. Conclusion During CT-guided cryoablation of porcine liver, low-keV VMI reconstructions derived from PCD-CT data sets exhibit improved thermal sensitivity being highest between + 20 and − 15 °C. 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Materials and Methods CT-guided cryoablation was performed using an ex vivo model of porcine liver on a PCD-CT system. The ablation zone was imaged continuously for 8 min by acquiring a CT scan every 5 s. Tissue temperature was measured using fiberoptic temperature probes placed parallel to the cryoprobe. CT-values and noise were measured at the tip of the temperature probes on each scan and on VMI series from 40 to 130 keV. Correlation of CT-values and temperature was assessed using linear regression analyses. Results For the whole temperature range of [− 40, + 20] °C, we observed a linear correlation between CT-values and temperature in reference 70 keV images ( R 2  = 0.60, p  &lt; 0.001) with a thermal sensitivity of 1.4 HU / °C . For the most dynamic range of [− 15, + 20] °C, the sensitivity increased to 2.4 HU / °C ( R 2  = 0.50, p  &lt; 0.001). 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subjects Ablation
Cardiology
Computed tomography
Datasets
Heat detection
Imaging
Laboratory Investigation
Liver
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Photons
Probes
Radiology
Sensitivity
Temperature probes
Ultrasound
title Improved Thermal Sensitivity Using Virtual Monochromatic Imaging Derived from Photon Counting Detector CT Data Sets: Ex Vivo Results of CT-Guided Cryoablation in Porcine Liver
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