Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness

Although ion transporters and channels have been extensively studied over the last couple of decades, there are still unresolved aspects with regards to their contribution to cancer cell biology. Recent work by Folcher et al (2023) reports a critical role for Na + leak channel NALCN in metastatic pr...

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Bibliographic Details
Published in:The EMBO journal 2023-10, Vol.42 (19), p.e114986-e114986
Main Authors: Stejerean‐Todoran, Ioana, Bogeski, Ivan
Format: Article
Language:English
Subjects:
Calcium ions
Calcium signalling
Metastases
Prostate cancer
Sodium
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Summary:Although ion transporters and channels have been extensively studied over the last couple of decades, there are still unresolved aspects with regards to their contribution to cancer cell biology. Recent work by Folcher et al (2023) reports a critical role for Na + leak channel NALCN in metastatic prostate cancer. The study demonstrates that NALCN promotes metastatic spread to distant organs by controlling Ca 2+ signaling.
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.2023114986