Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria

• Published in: EBioMedicine 2023-10, Vol.96, p.104805, Article 104805
• Main Authors: Mukaka, Mavuto, Onyamboko, Marie A., Olupot-Olupot, Peter, Peerawaranun, Pimnara, Suwannasin, Kanokon, Pagornrat, Watcharee, Kouhathong, Jindarat, Madmanee, Wanassanan, Were, Winifred, Namayanja, Cate, Onyas, Peter, Titin, Harriet, Baseke, Joy, Muhindo, Rita, Kayembe, Daddy K., Ndjowo, Pauline O., Basara, Benjamin B., Bongo, Georgette S., Okalebo, Charles B., Abongo, Grace, Uyoga, Sophie, Williams, Thomas N., Taya, Chiraporn, Dhorda, Mehul, Dondorp, Arjen M., Waithira, Naomi, Imwong, Mallika, Maitland, Kathryn, Fanello, Caterina, Day, Nicholas P.J., Tarning, Joel, White, Nicholas J., Taylor, Walter R.J.
• Format: Article
• Language: English
• Subjects: Age-based dosing; Antimalarials; Artemether - therapeutic use; Artemether, Lumefantrine Drug Combination - therapeutic use; Artemisinins; Child; Child, Preschool; Chromatography, Liquid; Cytochrome P-450 CYP2D6 - therapeutic use; Hemoglobins; Humans; Malaria, Falciparum - drug therapy; Plasmodium falciparum; Primaquine; Primaquine - pharmacokinetics; Primaquine - therapeutic use; Tandem Mass Spectrometry; Transmission blocking; Uganda
• ISSN: 2352-3964; 2352-3964
• DOI: 10.1016/j.ebiom.2023.104805

There are no pharmacokinetic data of single low dose primaquine (SLDPQ) as transmission blocking in African children with acute Plasmodium falciparum and glucose-6-phosphate dehydrogenase deficiency (G6PDd). Primaquine pharmacokinetics of age-dosed SLDPQ (shown previously to be gametocytocidal with similar tolerability as placebo) were characterised in falciparum-infected Ugandan and Congolese children aged 6 months to 11 years, treated on admission with standard 3-day dihydroartemisinin-piperaquine or artemether-lumefantrine plus SLDPQ: 6 m–