The Human Mpox Global Outbreak: Available Control Tools and the Opportunity to Break a Cycle of Neglect in Endemic Countries

The 2022 global outbreak of human Mpox (formerly monkeypox) virus (MPXV) infection outside of the usual endemic zones in Africa challenged our understanding of the virus's natural history, transmission dynamics, and risk factors. This outbreak has highlighted the need for diagnostics, vaccines,...

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Published in:The American journal of tropical medicine and hygiene 2023-10, Vol.109 (4), p.719-724
Main Authors: Nachega, Jean B, Mbala-Kingebeni, Placide, Rosenthal, Philip J, Rimoin, Anne W, Hoff, Nicole A, Liesenborghs, Laurens, Vanlerberghe, Veerle, Andrei, Graciela, Rawat, Angeli, Wilson, Lindsay A, Forrest, Jamie, Mills, Edward J, Hermans, Michel P, Mulangu, Sabue, Ntoumi, Francine, Zumla, Alimuddin, Muyembe-Tamfum, Jean-Jacques
Format: Article
Language:English
Subjects:
Animals
Disease control
Disease Outbreaks - prevention & control
Disease transmission
Endemic Diseases - prevention & control
Epidemics
Global Health
Health risks
Humans
Monkeypox virus
Mpox
Mpox (monkeypox) - epidemiology
Mpox (monkeypox) - prevention & control
Pathogens
Review
Zoonoses - epidemiology
Zoonoses - prevention & control
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Summary:The 2022 global outbreak of human Mpox (formerly monkeypox) virus (MPXV) infection outside of the usual endemic zones in Africa challenged our understanding of the virus's natural history, transmission dynamics, and risk factors. This outbreak has highlighted the need for diagnostics, vaccines, therapeutics, and implementation research, all of which require more substantial investments in equitable collaborative partnerships. Global multidisciplinary networks need to tackle MPXV and other neglected emerging and reemerging zoonotic pathogens to address them locally and prevent or quickly control their worldwide spread. Political endorsement from individual countries and financial commitments to maintain control efforts will be essential for long-term sustainability.
ISSN:0002-9637
1476-1645
1476-1645
DOI:10.4269/ajtmh.23-0161