Prospective quantitative study: Doppler ultrasound in the evaluation of chronic renal allograft disease and correlation with histopathological finding

• Published in: Annals of medicine and surgery 2023-10, Vol.85 (10), p.4811-4815
• Main Authors: Katwal, Shailendra, Suwal, Sundar, Bhandari, Rajan M., Chataut, Dinesh, Ansari, Mukhtar Alam, Lamichhane, Suman
• Format: Article
• Language: English
• Subjects: Original Research
• ISSN: 2049-0801; 2049-0801
• DOI: 10.1097/MS9.0000000000001251

Background and ObjectivesRenal allograft biopsy is the gold standard for diagnosing chronic allograft nephropathy, but noninvasive methods are needed to avoid unnecessary biopsies. Doppler ultrasonography, particularly the resistive index (RI), correlates with renal allograft dysfunction. This study aims to assess the relationship between renal sonographic parameters and biochemical parameters in diagnosing graft interstitial fibrosis. MethodsThe study evaluated 60 renal allograft recipients for sonographic renal morphological features and Doppler indices. The estimated glomerular filtration rate (eGFR) was calculated, and cortical fibrosis after the biopsy was determined using the Banff score. Continuous variables like mean and SD were calculated, and categorical variables were reported using frequencies and proportions. Associations were examined using independent sample t-tests, χ 2tests, and multivariate regression analysis. ResultsThe mean eGFR was 75.23±25.45 ml/min/1.73 m2. A significant correlation of eGFR with RI (r=0.341, P=0.008) was seen. A significant difference in mean RI (F=10.167; df=2,57; P