The expression of hypoxia inducible factor-1 alpha in diffuse large B-cell lymphoma (DLBCL) patients: a cross-sectional study in Indonesia

IntroductionHypoxia fuels cancer growth by supporting blood vessel formation, suppressing immune response, and helping cancer cells adapt to harsh surroundings. This happens when cancer cells react to low oxygen levels by activating hypoxia inducible factor-1 alpha (HIF-1α). High levels of HIF-1α ca...

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Published in:Annals of medicine and surgery 2023-10, Vol.85 (10), p.4780-4787
Main Authors: Pangarsa, Eko Adhi, Rizky, Daniel, Tandarto, Kevin, Naibaho, Ridho M., Kurniawan, Sigit P., Istiadi, Hermawan, Puspasari, Dik, Santoso, Antonius Gunawan, Setiawan, Budi, Santosa, Damai, Haryana, Sofia Mubarika, Suharti, Catharina
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Language:English
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Summary:IntroductionHypoxia fuels cancer growth by supporting blood vessel formation, suppressing immune response, and helping cancer cells adapt to harsh surroundings. This happens when cancer cells react to low oxygen levels by activating hypoxia inducible factor-1 alpha (HIF-1α). High levels of HIF-1α can indicate an aggressive form of cancer and resistance to treatment in diffuse large B-cell lymphoma (DLBCL) patients. This study aimed to identify which factors are linked to HIF-1α distribution using immunohistochemistry in DLBCL patients.MethodThis study conducted at a hospital in Indonesia between 2020 and 2022 aimed to investigate factors associated with HIF-1α expression in DLBCL patients. Newly diagnosed DLBCL patients were categorized into two groups based on HIF-1α distribution (
ISSN:2049-0801
2049-0801
DOI:10.1097/MS9.0000000000001162