THU635 Metabolic Characteristics Among Polycystic Ovary Syndrome-Phenotypes In A Sample Of Hispanic Patients

• Published in: Journal of the Endocrine Society 2023-10, Vol.7 (Supplement_1)
• Main Authors: Gonzalez-Rodriguez, Loida Alejandra, Arroyo, Isabel C, Diaz-Rios, Beatriz, González-Sepúlveda, Lorena, Casas-Loyola, Cristina M, Bermúdez-Santos, Jadailine, Pérez-Cardona, Cynthia, Romaguera, Josefina, Azziz, Ricardo
• Format: Article
• Language: English
• Subjects: Reproductive Endocrinology
• ISSN: 2472-1972; 2472-1972
• DOI: 10.1210/jendso/bvad114.1539

Disclosure: L.A. Gonzalez-Rodriguez: Research Investigator; Self; Eli Lilly & Company. I.C. Arroyo: None. B. Diaz-Rios: None. L. González-Sepúlveda: None. C.M. Casas-Loyola: None. J. Bermúdez-Santos: None. C. Pérez-Cardona: None. J. Romaguera: None. R. Azziz, MD, MBA, MPH: Advisory Board Member; Self; Arora Forge. Consulting Fee; Self; Rani Therapeutics, Spruce Biosciences, Fortress Biotech, Core Access Surgical Technologies. Grant Recipient; Self; Ferring Pharmaceuticals. Stock Owner; Self; Martin Imaging. PURPOSE: Polycystic Ovary Syndrome (PCOS), a common endocrinopathy affecting women in their reproductive years, is associated with an increased risk for cardiometabolic comorbidities. Even though PCOS is a common condition, there is often a delay in diagnosis and treatment due to several proposed diagnostic criteria. Due to the complexity of this syndrome and different clinical manifestations, it has been recommended to identify their 4 phenotypes. This study aimed to compare the clinical and metabolic characteristics among PCOS-phenotypes in a sample of Hispanic patients. METHODS: This is a cross-sectional study of females between 21-45 years of age with confirmed PCOS using the Rotterdam criteria. Patients were classified according to phenotypes: A, hyperandrogenism (HA), oligoovulation/menstrual dysfunction (OA/MD), and polycystic ovarian morphology (PCOM); B, HA + OA/MD; C, HA + PCOM; D, OA/MD + PCOM. Metabolic Syndrome (MetS) was diagnosed using ATP III criteria. Metabolic characteristics were compared between groups. RESULTS: Sixty-three patients with PCOS were evaluated with phenotypes A (60%), B (21%), C (5%), and D (14%). Only 26 patients (41%) had a previous diagnosis of PCOS. The prevalence of MetS in this sample was 52.4%. Among the phenotypes, phenotype B had the higher prevalence of MetS (61.5%) followed by phenotype D (55.6%) and phenotype A (52.6%). Significant differences in obesity, waist, and hip circumference were found, with phenotype-C having lower parameters (p ≤ 0.05). A tendency for lower BMI, waist-to-hip-ratio, HOMA-IR, and hs-CRP levels was also observed in phenotype-C. CONCLUSION: Our study found a high prevalence of MetS in this sample of patients with PCOS; phenotypes affected by menstrual dysregulation having a higher prevalence. Less than half of patients with PCOS were previously diagnosed despite multiple medical evaluations for symptoms, which emphasizes the importance of an early diagnosis to avoid cardiometabolic co