4-Amino-5-Hexynoic Acid—A Potent Inhibitor of Tetrapyrrole Biosynthesis in Plants 1

4-Amino-5-hexynoic acid, a suicide inactivator of the mammalian pyridoxal phosphate-dependent 4-aminobutyric acid:2-oxoglutaric acid aminotransferase, inhibits phytochrome and chlorophyll synthesis in developing oat ( Avena sativa L.), corn ( Zea mays L.), pea ( Pisum sativum L.), and cucumber ( Cuc...

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Bibliographic Details
Published in:Plant physiology (Bethesda) 1988-11, Vol.88 (3), p.747-751
Main Authors: Elich, Tedd D., Lagarias, J. Clark
Format: Article
Language:English
Subjects:
Metabolism and Enzymology
Online Access:Get full text
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Summary:4-Amino-5-hexynoic acid, a suicide inactivator of the mammalian pyridoxal phosphate-dependent 4-aminobutyric acid:2-oxoglutaric acid aminotransferase, inhibits phytochrome and chlorophyll synthesis in developing oat ( Avena sativa L.), corn ( Zea mays L.), pea ( Pisum sativum L.), and cucumber ( Cucumis sativus L.) seedlings. In Avena and Cucumis seedlings, respectively, inhibition of phytochrome and chlorophyll accumulation by 4-amino-5-hexynoic acid can be significantly reversed by application of 5-aminolevulinic acid. These results indicate that 4-amino-5-hexynoic acid inhibits the synthesis of 5-aminolevulinic acid in plants.
ISSN:0032-0889
1532-2548