A Rare Case of Kounis Syndrome Secondary to Infliximab

Kounis syndrome (KS) is an acute coronary syndrome triggered by allergic or anaphylactic reactions. It manifests as coronary artery vasospasm, acute myocardial infarction, or coronary stent thrombosis, resulting from inflammatory cytokine release and inappropriate activation of platelets and mast ce...

Full description

Saved in:
Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-09, Vol.15 (9)
Main Authors: Diaz-Rodriguez, Porfirio E, Molina-Lopez, Victor H, Gonzalez Burgos, Benjamin A, Nieves-La Cruz, Carlos
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Allergy/Immunology
Anaphylaxis
Angina pectoris
Cardiology
Cardiovascular disease
Case reports
Clinical outcomes
Coronary vessels
Crohn's disease
Cytokines
Electrocardiography
Enzymes
Heart attacks
Insect bites
Internal Medicine
Ischemia
Medical imaging
Monoclonal antibodies
Patients
Thrombosis
Tumor necrosis factor-TNF
Ultrasonic imaging
Vein & artery diseases
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Kounis syndrome (KS) is an acute coronary syndrome triggered by allergic or anaphylactic reactions. It manifests as coronary artery vasospasm, acute myocardial infarction, or coronary stent thrombosis, resulting from inflammatory cytokine release and inappropriate activation of platelets and mast cells. We present a case of an 85-year-old male with Crohn's disease who suffered anaphylaxis during infliximab infusion, culminating in non-ST myocardial infarction (NSTEMI). The patient's symptoms were effectively managed with epinephrine and diphenhydramine, and KS secondary to infliximab was diagnosed. Diagnosing KS can be challenging due to the overlapping signs of an allergic reaction and myocardial infarction. Timely recognition and appropriate management of KS are crucial to enhance patient outcomes. Therefore, healthcare providers should maintain a high index of suspicion for KS in patients with acute coronary syndromes linked to allergic reactions to optimize care and minimize potential risks. This case report underscores the significance of prompt intervention and awareness of Kounis syndrome in clinical practice.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.44704