Association between anti‐endothelial antigen antibodies and allograft rejection in kidney transplantation

BackgroundEndothelial cells are vital in the transplant immune system as semiprofessional antigen-presenting cells. Few studies have investigated the importance of anti-endothelin subtype A receptor (ETAR) antibodies in kidney transplantation. Here, we aimed to analyze the association between anti-a...

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Bibliographic Details
Published in:Journal of clinical laboratory analysis 2023-08, Vol.37 (15-16), p.e24961-e24961
Main Authors: Lee, Hyun Ji, Shin, Kyung‐Hwa, Kim, Il Young, Choi, Byung Hyun, Kim, Hyung‐Hoi
Format: Article
Language:English
Subjects:
Allografts
Angiotensin
Angiotensin II
Antibodies
Antigen-presenting cells
Antigens
Diabetes
Endothelial cells
Endothelins
Endothelium
Graft rejection
Histocompatibility antigen HLA
Immune system
Inflammation
Kidney transplantation
Kidney transplants
Lymphocytes
Lymphocytes T
Patients
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Summary:BackgroundEndothelial cells are vital in the transplant immune system as semiprofessional antigen-presenting cells. Few studies have investigated the importance of anti-endothelin subtype A receptor (ETAR) antibodies in kidney transplantation. Here, we aimed to analyze the association between anti-angiotensin II type I receptor (AT1R) and anti-ETAR antibodies and the association between the presence of anti-endothelial antibodies and the risk of allograft rejection in kidney transplantation.MethodsIn total, 252 patients who underwent kidney transplantation were enrolled in this study. Antibodies for human leukocyte antigens (HLAs) and non-HLAs were analyzed immediately before transplantation. Patients were categorized based on the occurrence of antibody-mediated rejection (AMR) or T-cell-mediated rejection (TCMR) by 2017 Banff classification. All p-values were two-tailed, and statistical significance was set at p 
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.24961