European Network for ICU-Related Respiratory Infections (ENIRRIs): a multinational, prospective, cohort study of nosocomial LRTI

• Published in: Intensive care medicine 2023-10, Vol.49 (10), p.1212-1222
• Main Authors: Martin-Loeches, Ignacio, Reyes, Luis Felipe, Nseir, Saad, Ranzani, Otavio, Povoa, Pedro, Diaz, Emili, Schultz, Marcus J., Rodríguez, Alejandro H., Serrano-Mayorga, Cristian C., De Pascale, Gennaro, Navalesi, Paolo, Panigada, Mauro, Coelho, Luis Miguel, Skoczynski, Szymon, Esperatti, Mariano, Cortegiani, Andrea, Aliberti, Stefano, Caricato, Anselmo, Salzer, Helmut J. F., Ceccato, Adrian, Civljak, Rok, Soave, Paolo Maurizio, Luyt, Charles-Edouard, Ekren, Pervin Korkmaz, Rios, Fernando, Masclans, Joan Ramon, Marin, Judith, Iglesias-Moles, Silvia, Nava, Stefano, Chiumello, Davide, Bos, Lieuwe D., Artigas, Antoni, Froes, Filipe, Grimaldi, David, Taccone, Fabio Silvio, Antonelli, Massimo, Torres, Antoni
• Format: Article
• Language: English
• Subjects: Acute respiratory distress syndrome; Analysis; Anesthesiology; Antimicrobial resistance; Bacterial pneumonia; Care and treatment; Cohort analysis; Critical Care Medicine; Drug resistance in microorganisms; Emergency Medicine; Health aspects; Hospital patients; Hospitals; Intensive; Klebsiella; Mechanical ventilation; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Microbiology; Microorganisms; Mortality; Multidrug resistance; NCT; NCT03183921; Nosocomial infection; Observational studies; Original; Pain Medicine; Pathogens; Patients; Pediatrics; Pneumology/Respiratory System; Pneumonia; Procalcitonin; Respiratory distress syndrome; Respiratory tract; Respiratory tract infection; Septic shock; Tracheobronchitis; Value-added tax; Ventilation; Ventilator-associated pneumonia; Ventilators
• ISSN: 0342-4642; 1432-1238
• DOI: 10.1007/s00134-023-07210-9

Purpose Lower respiratory tract infections (LRTI) are the most frequent infectious complication in patients admitted to the intensive care unit (ICU). We aim to report the clinical characteristics of ICU-admitted patients due to nosocomial LRTI and to describe their microbiology and clinical outcomes. Methods A prospective observational study was conducted in 13 countries over two continents from 9th May 2016 until 16th August 2019. Characteristics and outcomes of ventilator-associated pneumonia (VAP), ventilator-associated tracheobronchitis (VAT), ICU hospital-acquired pneumonia (ICU-HAP), HAP that required invasive ventilation (VHAP), and HAP in patients transferred to the ICU without invasive mechanical ventilation were collected. The clinical diagnosis and treatments were per clinical practice and not per protocol. Descriptive statistics were used to compare the study groups. Results 1060 patients with LRTI (72.5% male sex, median age 64 [50–74] years) were included in the study; 160 (15.1%) developed VAT, 556 (52.5%) VAP, 98 (9.2%) ICU-HAP, 152 (14.3%) HAP, and 94 (8.9%) VHAP. Patients with VHAP had higher serum procalcitonin (PCT) and Sequential Organ Failure Assessment (SOFA) scores. Patients with VAP or VHAP developed acute kidney injury, acute respiratory distress syndrome, multiple organ failure, or septic shock more often. One thousand eight patients had microbiological samples, and 711 (70.5%) had etiological microbiology identified. The most common microorganisms were Pseudomonas aeruginosa (18.4%) and Klebsiella spp (14.4%). In 382 patients (36%), the causative pathogen shows some antimicrobial resistance pattern. ICU, hospital and 28-day mortality were 30.8%, 37.5% and 27.5%, respectively. Patients with VHAP had the highest ICU, in-hospital and 28-day mortality rates. Conclusion VHAP patients presented the highest mortality among those admitted to the ICU. Multidrug-resistant pathogens frequently cause nosocomial LRTI in this multinational cohort study.