A highlight on carbamazepine-induced adverse drug reactions in Saudi Arabia: a retrospective medical records-based study

The link between human leukocyte antigen (HLA) alleles and carbamazepine-induced cutaneous, respiratory, and gastrointestinal adverse drug reactions (ADR) has created a window of opportunity for preventing certain forms of cutaneous adverse drug reactions (cADRs); however, there is not enough data t...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2023-11, Vol.396 (11), p.3177-3182
Main Authors: Sukkarieh, Hatouf H., Khokhar, Ayesha A., Bustami, Rami T., Karbani, Gulsan A., Alturki, Fatimah A., Alvi, Syed N.
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants - adverse effects
Benzodiazepines
Biomedical and Life Sciences
Biomedicine
Carbamazepine
Carbamazepine - adverse effects
Child
Convulsions & seizures
Drug-Related Side Effects and Adverse Reactions - epidemiology
Epilepsy
Epilepsy - chemically induced
Epilepsy - drug therapy
Epilepsy - genetics
Histocompatibility antigen HLA
Humans
Medical Records
Neurosciences
Pharmacogenomics
Pharmacology/Toxicology
Retrospective Studies
Saudi Arabia
Seizures
Seizures - drug therapy
Side effects
Statistical analysis
Statistics
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Summary:The link between human leukocyte antigen (HLA) alleles and carbamazepine-induced cutaneous, respiratory, and gastrointestinal adverse drug reactions (ADR) has created a window of opportunity for preventing certain forms of cutaneous adverse drug reactions (cADRs); however, there is not enough data to make pharmacogenomic recommendations that can be implemented globally. The aim of this study is to assess and document carbamazepine-induced adverse reactions among prescribed Saudi/non-Saudi patients. A retrospective chart review was performed for patients who received carbamazepine (CBZ) in the period between 2016 and 2020, in the Kingdom of Saudi Arabia. Data were gathered and descriptive statistical analyses were performed on the data for the study sample. Comparisons were made using the chi-square test or independent samples’ t -test. Statistical significance was considered at p  
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-023-02525-2