Gallstone Disease and Its Correlation With Thyroid Disorders: A Narrative Review

Over the years, several studies have revealed an important link between thyroid disorders and gallstone disease. According to these studies, hypothyroidism and hyperthyroidism are associated with cholesterol gallstone disease. This association between thyroid hormone disorders and cholesterol gallst...

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Published in:Curēus (Palo Alto, CA) CA), 2023-09, Vol.15 (9), p.e45116-e45116
Main Authors: Ravi, Phanish Chandra, Thugu, Thanmai Reddy, Singh, Jugraj, Dasireddy, Rachana Reddy, Kumar, Sharanya Anil, Isaac, Natasha Varghese, Oladimeji, Abiodun, DeTrolio, Victoria, Abdalla, Rasha, Mohan, Vineetha, Iqbal, Javed
Format: Article
Language:English
Subjects:
Bile
Biosynthesis
Cholesterol
Enzymes
Fatty acids
Gallstones
Gastroenterology
Genes
Homeostasis
Hyperthyroidism
Hypothyroidism
Internal Medicine
Lipids
Liver
Medical Education
Metabolism
Sterols
Thyroid gland
Triglycerides
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Summary:Over the years, several studies have revealed an important link between thyroid disorders and gallstone disease. According to these studies, hypothyroidism and hyperthyroidism are associated with cholesterol gallstone disease. This association between thyroid hormone disorders and cholesterol gallstone disease is due to the importance of thyroid hormones on cholesterol synthesis, bile functioning and content, and gallbladder motility. Several genes and receptors have been found on the thyroid gland, liver, and gallbladder to verify this association. These genes affect thyroid hormone secretion, lipid metabolism, and bile secretion. Defects in these various gene expression and protein functions lead to bile duct diseases. Other causes that lead to cholesterol gallstone disease are supersaturation of the bile with cholesterol and impaired gallbladder motility, which leads to bile stasis. This article has discussed these factors in detail while highlighting the association between thyroid hormones and cholesterol gallstone disease.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.45116