A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism

We explored the toxicity and mutagenicity of a wide range of xenobiotic nucleoside triphosphates to an Escherichia coli strain equipped with a nucleoside triphosphate transporter. This bacterial test provides a tool to evaluate and guide the synthesis of nucleotides for applications such as the prop...

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Bibliographic Details
Published in:RSC advances 2023-10, Vol.13 (43), p.29862-29865
Main Authors: Blanchard, Aude, Abramov, Mikhail, Hassan, Camille, Marlière, Philippe, Herdewijn, Piet, Pezo, Valérie
Format: Article
Language:English
Subjects:
Chemistry
E coli
Life Sciences
Mutagenicity
Nucleosides
Nucleotides
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Summary:We explored the toxicity and mutagenicity of a wide range of xenobiotic nucleoside triphosphates to an Escherichia coli strain equipped with a nucleoside triphosphate transporter. This bacterial test provides a tool to evaluate and guide the synthesis of nucleotides for applications such as the propagation of non-natural genetic information or the selection of potential drugs. Impact of xenobiotic nucleoside triphosphates on E. coli nucleic acids synthesis.
ISSN:2046-2069
2046-2069
DOI:10.1039/d3ra06172h