Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions as the intestinal barrier of preterm infants matures

Abstract Previous work has shown that Secretory-IgA (SIgA) binding to the intestinal microbiota is variable and may regulate host inflammatory bowel responses. Nevertheless, the impact of the SIgA functional binding to the microbiota remains largely unknown in preterm infants whose immature epitheli...

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Bibliographic Details
Published in:Clinical and experimental immunology 2023-10, Vol.213 (3), p.339-356
Main Authors: Mahdally, Sarah M, Izquierdo, Mariana, Viscardi, Rose M, Magder, Laurence S, Crowley, Helena M, Bafford, Andrea C, Drachenberg, Cinthia B, Farfan, Mauricio J, Fasano, Alessio, Sztein, Marcelo B, Salerno-Goncalves, Rosangela
Format: Article
Language:English
Subjects:
Gastrointestinal Microbiome
Humans
Immunoglobulin A, Secretory - metabolism
Infant, Newborn
Infant, Premature
Inflammation
Inflammation/Inflammatory Disease
Intestines
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Summary:Abstract Previous work has shown that Secretory-IgA (SIgA) binding to the intestinal microbiota is variable and may regulate host inflammatory bowel responses. Nevertheless, the impact of the SIgA functional binding to the microbiota remains largely unknown in preterm infants whose immature epithelial barriers make them particularly susceptible to inflammation. Here, we investigated SIgA binding to intestinal microbiota isolated from stools of preterm infants
ISSN:0009-9104
1365-2249
1365-2249
DOI:10.1093/cei/uxad042