SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer

In the field of oncology, the Signaling Lymphocyte Activation Molecule (SLAM) family is emerging as pivotal in modulating immune responses within tumor environments. The SLAM family comprises nine receptors, mainly found on immune cell surfaces. These receptors play complex roles in the interaction...

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Bibliographic Details
Published in:Cancers 2023-09, Vol.15 (19), p.4808
Main Authors: Tojjari, Alireza, Giles, Francis J, Vilbert, Maysa, Saeed, Anwaar, Cavalcante, Ludimila
Format: Article
Language:English
Subjects:
Antigens
B cells
Cancer
Cancer therapies
Care and treatment
CD150 antigen
Cell activation
Clinical trials
Colorectal cancer
Colorectal carcinoma
Cytokines
Cytotoxicity
Development and progression
Disease
Haplotypes
Health aspects
Immune response
Immune system
Immunology
Immunomodulation
Immunotherapy
Leukemia
Ligands
Lymphocytes
Medical prognosis
Medical research
Medicine, Experimental
Melanoma
Multiple myeloma
Oncology
Patients
Review
RNA
RNA sequencing
Roles
T cell receptors
Tumors
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Summary:In the field of oncology, the Signaling Lymphocyte Activation Molecule (SLAM) family is emerging as pivotal in modulating immune responses within tumor environments. The SLAM family comprises nine receptors, mainly found on immune cell surfaces. These receptors play complex roles in the interaction between cancer and the host immune system. Research suggests SLAM’s role in both enhancing and dampening tumor-immune responses, influencing the progression and treatment outcomes of various cancers. As immunotherapy advances, resistance remains an issue. The nuanced roles of the SLAM family might provide answers. With the rise in technologies like single-cell RNA sequencing and advanced imaging, there is potential for precise SLAM-targeted treatments. This review stresses patient safety, the importance of thorough clinical trials, and the potential of SLAM-focused therapies to transform cancer care. In summary, SLAM’s role in oncology signals a new direction for more tailored and adaptable cancer treatments.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15194808