Dynamics of the Microbiota and Its Relationship with Post-COVID-19 Syndrome

Coronavirus disease (COVID-19) is an infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can be asymptomatic or present with multiple organ dysfunction. Many infected individuals have chronic alterations associated with neuropsychiatric, endocrine, gastrointestina...

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Published in:International journal of molecular sciences 2023-10, Vol.24 (19), p.14822
Main Authors: Moreno-Corona, Nidia Carolina, López-Ortega, Orestes, Pérez-Martínez, Cesar Augusto, Martínez-Castillo, Macario, De Jesús-González, Luis Adrián, León-Reyes, Guadalupe, León-Juárez, Moisés
Format: Article
Language:English
Subjects:
B cells
Bacteria
Coronaviruses
COVID-19
Development and progression
Dyspnea
Health aspects
HIV
Homeostasis
Human immunodeficiency virus
Immune system
Infections
Inflammation
Influenza
Long COVID
Lung diseases
Lungs
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Pathogens
Remission (Medicine)
Review
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Viral infections
Virus diseases
Viruses
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Summary:Coronavirus disease (COVID-19) is an infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can be asymptomatic or present with multiple organ dysfunction. Many infected individuals have chronic alterations associated with neuropsychiatric, endocrine, gastrointestinal, and musculoskeletal symptoms, even several months after disease onset, developing long-COVID or post-acute COVID-19 syndrome (PACS). Microbiota dysbiosis contributes to the onset and progression of many viral diseases, including COVID-19 and post-COVID-19 manifestations, which could serve as potential diagnostic and prognostic biomarkers. This review aimed to discuss the most recent findings on gut microbiota dysbiosis and its relationship with the sequelae of PACS. Elucidating these mechanisms could help develop personalized and non-invasive clinical strategies to identify individuals at a higher risk of experiencing severe disease progression or complications associated with PACS. Moreover, the review highlights the importance of targeting the gut microbiota composition to avoid dysbiosis and to develop possible prophylactic and therapeutic measures against COVID-19 and PACS in future studies.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241914822