The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls

Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet. Thus, we aimed to investigate the association between 25-hy...

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Published in:Nutrients 2023-09, Vol.15 (19), p.4111
Main Authors: Leser, Bernadette, Dalkner, Nina, Tmava-Berisha, Adelina, Fellendorf, Frederike T., Unterrainer, Human-Friedrich, Stross, Tatjana, Maget, Alexander, Platzer, Martina, Bengesser, Susanne A., Häussl, Alfred, Zwigl, Ina, Birner, Armin, Queissner, Robert, Stix, Katharina, Wels, Linda, Schönthaler, Elena M. D., Lenger, Melanie, Schwerdtfeger, Andreas R., Zelzer, Sieglinde, Herrmann, Markus, Reininghaus, Eva Z.
Format: Article
Language:English
Subjects:
Alfacalcidol
Bipolar disorder
Brain
Calcifediol
Cognition
Dopamine
Executive function
Medical research
Medicine, Experimental
Memory
Mental disorders
Metabolism
Metabolites
Physiological aspects
Psychiatrists
Psychologists
Vitamin D
Vitamin deficiency
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Summary:Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet. Thus, we aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D), 24,25 dihydroxyvitamin D (24,25(OH)2D, the vitamin D metabolite ratio (VMR) and cognition in a cohort of euthymic patients with bipolar disorder. Vitamin D metabolites were measured simultaneously by liquid-chromatography tandem mass-spectrometry in serum samples from 86 outpatients with bipolar disorder and 93 healthy controls. Neither the inactive precursor 25(OH)D, nor the primary vitamin D catabolite 24,25(OH)2D, or the vitamin D metabolite ratio were significantly associated with the domains “attention”, “memory”, or “executive function” in individuals with bipolar disorder and healthy controls. Further, no vitamin D deficiency effect or interaction group × vitamin D deficiency was found in the cognitive domain scores. In summary, the present study does not support vitamin D metabolism as a modulating factor of cognitive function in euthymic BD patients. Considering the current study’s cross-sectional design, future research should expand these results in a longitudinal setting and include additional aspects of mental health, such as manic or depressive symptoms, long-term illness course and psychopharmacological treatment.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15194111