Real-world Prescription Patterns and Patient Satisfaction Regarding Maintenance Therapy of Gastroesophageal Reflux Disease: An Observational, Cross-sectional, Multicenter Study

• Published in: Journal of neurogastroenterology and motility 2023-10, Vol.29 (4), p.470-477
• Main Authors: Huh, Cheal Wung, Son, Nak Hoon, Youn, Young Hoon, Jung, Da Hyun, Kim, Min Kyung, Gong, Eun Jeong, Huh, Kyu Chan, Kim, Seung Young, Park, Moo In, Lee, Ju Yup, Kwon, Joong Goo, Kim, Jae Hak, Shin, Cheol Min, Jung, Kee Wook, Hong, Su Jin, Kim, Hee Man, Choi, Suck Chei, Jung, Hye-Kyung, Kim, Hyun Jin, Lee, Kwang Jae
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 2093-0879; 2093-0887
• DOI: 10.5056/jnm23088

Background/AimsGastroesophageal reflux disease (GERD) is a common chronic gastrointestinal disorder that typically requires long-term maintenance therapy. However, little is known about patient preferences and satisfaction and real-world prescription patterns regarding maintenance therapy for GERD.MethodsThis observational, cross-sectional, multicenter study involved patients from 18 referral hospitals in Korea. We surveyed patients who had been prescribed proton pump inhibitors (PPIs) for GERD for at least 90 days with a minimum follow-up duration of 1 year. The main outcome was overall patient satisfaction with different maintenance therapy modalities.ResultsA total of 197 patients were enrolled. Overall patient satisfaction, patient preferences, and GERD health-related quality of life scores did not significantly differ among the maintenance therapy modality groups. However, the on-demand therapy group experienced a significantly longer disease duration than the continuous therapy group. The continuous therapy group demonstrated a lower level of awareness of potential adverse effects associated with PPIs than the on-demand therapy group but received higher doses of PPIs than the on-demand therapy group. The prescribed doses of PPIs also varied based on the phenotype of GERD, with higher doses prescribed for non-erosive reflux disease than erosive reflux disease.ConclusionAlthough overall patient satisfaction did not significantly differ among the different PPI maintenance therapy modality groups, awareness of potential adverse effects was significantly different between the on-demand and continuous therapy groups.