Identifying Mediators of Intervention Effects Within a Randomized Controlled Trial to Motivate Cancer Genetic Risk Assessment Among Breast and Ovarian Cancer Survivors

• Published in: Annals of behavioral medicine 2023-10, Vol.57 (11), p.965-977
• Main Authors: An, Jinghua, Lu, Shou-En, McDougall, Jean, Walters, Scott T, Lin, Yong, Heidt, Emily, Stroup, Antoinette, Paddock, Lisa, Grumet, Sherry, Toppmeyer, Deborah, Kinney, Anita Y
• Format: Article
• Language: English
• Subjects: Breast Neoplasms - genetics; Breast Neoplasms - psychology; Cancer Survivors - psychology; Editor's Choice; Female; Genetic Counseling - psychology; Genetic Testing; Humans; Ovarian Neoplasms - genetics; Regular; Risk Assessment
• ISSN: 0883-6612; 1532-4796; 1532-4796
• DOI: 10.1093/abm/kaad048

Abstract Background A theory-guided Tailored Counseling and Navigation (TCN) intervention successfully increased cancer genetic risk assessment (CGRA) uptake among cancer survivors at increased risk of hereditary breast and ovarian cancer (HBOC). Understanding the pathways by which interventions motivate behavior change is important for identifying the intervention’s active components. Purpose We examined whether the TCN intervention exerted effects on CGRA uptake through hypothesized theoretical mediators. Methods Cancer survivors at elevated risk for HBOC were recruited from three statewide cancer registries and were randomly assigned to three arms: TCN (n = 212), Targeted Print (TP, n = 216), and Usual Care (UC, n = 213). Theoretical mediators from the Extended Parallel Process Model, Health Action Planning Approach, and Ottawa Decision Support Framework were assessed at baseline and 1-month follow-up; CGRA uptake was assessed at 6 months. Generalized structural equation modeling was used for mediation analysis. Results The TCN effects were most strongly mediated by behavioral intention alone (β = 0.49 and 0.31) and by serial mediation through self-efficacy and intention (β = 0.041 and 0.10) when compared with UC and TP, respectively. In addition, compared with UC, the TCN also increased CGRA through increased perceived susceptibility, knowledge of HBOC, and response efficacy. Conclusions Risk communication and behavioral change interventions for hereditary cancer should stress a person’s increased genetic risk and the potential benefits of genetic counseling and testing, as well as bolster efficacy beliefs by helping remove barriers to CGRA. System-level and policy interventions are needed to further expand access. Lay Summary It is recommended that cancer survivors at increased risk for heredity seek cancer genetic risk assessment (CGRA), which includes cancer genetic counseling and genetic testing. A Tailored Counseling and Navigation (TCN) intervention successfully increased CGRA uptake among women with a history of cancer who enrolled in a randomized controlled trial. Understanding reasons for TCN’s effectiveness can guide future interventions that use risk messages and behavior change techniques. We conducted mediation analyses, which enabled identification of the TCN’s active components. Eligible breast and ovarian cancer survivors (n = 641) were recruited from three statewide cancer registries and were assigned to three groups: TCN, Targeted Pri