Brain functional connectivity-based prediction of vagus nerve stimulation efficacy in pediatric pharmacoresistant epilepsy

Although vagus nerve stimulation (VNS) is a common and widely used therapy for pharmacoresistant epilepsy, the reported efficacy of VNS in pediatric patients varies, so it is unclear which children will respond to VNS therapy. This study aimed to identify functional brain network features associated...

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Bibliographic Details
Published in:CNS neuroscience & therapeutics 2023-11, Vol.29 (11), p.3259-3268
Main Authors: Chen, Hao, Wang, Yi, Ji, Taoyun, Jiang, Yuwu, Zhou, Xiao-Hua
Format: Article
Language:English
Subjects:
Biomarkers
Children & youth
Convulsions & seizures
EEG
Electrodes
Electroencephalography
Epilepsy
Neural networks
Original
Parietal lobe
Patients
Pediatrics
Postcentral gyrus
Prediction models
Time series
Vagus nerve
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Summary:Although vagus nerve stimulation (VNS) is a common and widely used therapy for pharmacoresistant epilepsy, the reported efficacy of VNS in pediatric patients varies, so it is unclear which children will respond to VNS therapy. This study aimed to identify functional brain network features associated with VNS action to distinguish VNS responders from nonresponders using scalp electroencephalogram (EEG) data. Twenty-three children were included in this study, 16 in the discovery cohort and 7 in the test cohort. Using partial correlation value as a measure of whole-brain functional connectivity, we identified the differential edges between responders and nonresponders. Results derived from this were used as input to generate a support vector machine-learning classifier to predict VNS outcomes. The postcentral gyrus in the left and right parietal lobe regions was identified as the most significant differential brain region between VNS responders and nonresponders (p 
ISSN:1755-5930
1755-5949
DOI:10.1111/cns.14257