Dyslipidemia and Obesity in Ischemic Stroke

• Published in: Curēus (Palo Alto, CA) CA), 2023-09, Vol.15 (9), p.e45409-e45409
• Main Authors: Gajurel, Bikram P, Gurung, Anju, Ojha, Rajeev, Rajbhandari, Reema, Karn, Ragesh
• Format: Article
• Language: English
• Subjects: Abdomen; Atherosclerosis; Cholesterol; Diabetes; Endocrinology/Diabetes/Metabolism; Females; Gender; High density lipoprotein; Hypertension; Ischemia; Lipids; Lipoproteins; Metabolic disorders; Neurology; Nutrition; Obesity; Regression analysis; Risk factors; Stroke; Tomography; Triglycerides
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.45409

BackgroundDyslipidemia and obesity are both important risk factors for the first and recurrent ischemic strokes. Dyslipidemia is highly prevalent among Asian populations, and the prevalence of obesity is also noted to be progressively increasing in this population. This study was carried out to determine the prevalence of dyslipidemia and central obesity and their association with each other and various cardiovascular risk factors among patients who presented with an acute ischemic stroke to a tertiary care university hospital in Nepal.MethodsThis study is a secondary analysis done on data from a prospective observational study that was carried out on patients who were either acutely admitted to or visited the outpatient department of the hospital with a diagnosis of ischemic stroke. Dyslipidemia was defined according to the third report of the National Cholesterol Education Program expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Obesity was defined as central obesity by measuring waist circumference. Data were collected by convenience sampling and analyzed by IBM Corp. Released 2019. IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY: IBM Corp. Significant variables were compared with logistic regression analysis. Other data were expressed as frequencies and percentages.ResultsOut of 145 patients, 77 were male (53.1%). The mean age of the patients was 60.15 years. Dyslipidemia and central obesity were present in 96.6% and 57.9% of the patients, respectively. The most common lipid abnormality was low-density lipoprotein cholesterol, present in 82.8% of the patients, followed by high triglycerides, present in 21.4% of them. Dyslipidemia was not associated with any vascular risk factors. Central obesity was significantly associated with female gender, diabetes, and low-density lipoprotein cholesterol in univariate analysis. However, in multivariate logistic regression analysis, it was significantly associated with only female gender (p=0.003) and diabetes (p=0.012).ConclusionDyslipidemia and central obesity are very common in patients with ischemic stroke. Dyslipidemia is not associated with any vascular risk factors. However, central obesity is significantly associated with the female gender and diabetes.