Intestinal Barrier Disruption with Plasmodium falciparum infection in pregnancy and risk of preterm birth: a cohort study

Malaria in early pregnancy is a risk factor for preterm birth and is associated with sustained inflammation and dysregulated angiogenesis across gestation. This study investigated whether malaria is associated with increased gut leak and whether this contributes to systemic inflammation, altered ang...

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Bibliographic Details
Published in:EBioMedicine 2023-11, Vol.97, p.104808-104808, Article 104808
Main Authors: Wright, Julie K., Weckman, Andrea M., Ngai, Michelle, Stefanova, Veselina, Zhong, Kathleen, McDonald, Chloe R., Elphinstone, Robyn E., Conroy, Andrea L., Coburn, Bryan A., Madanitsa, Mwayi, Taylor, Steve M., ter Kuile, Feiko O., Kain, Kevin C.
Format: Article
Language:English
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Summary:Malaria in early pregnancy is a risk factor for preterm birth and is associated with sustained inflammation and dysregulated angiogenesis across gestation. This study investigated whether malaria is associated with increased gut leak and whether this contributes to systemic inflammation, altered angiogenesis, and preterm birth. We quantified plasma concentrations of gut leak markers, soluble CD14 (sCD14) and lipopolysaccharide binding protein (LBP) from 1339 HIV-negative pregnant Malawians at
ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2023.104808