Complex cardiac implantable electronic device infections in Alberta, Canada: An epidemiologic cohort study of validated administrative data

• Published in: Infection control and hospital epidemiology 2023-10, Vol.44 (10), p.1607-1613
• Main Authors: King, Teagan L., Chew, Derek S., Leal, Jenine, Cannon, Kristine, Exner, Derek V., Smith, Stephanie, Larios, Oscar, Bush, Kathryn, Yuen, Brian, Zhang, Zuying, Rennert-May, Elissa
• Format: Article
• Language: English
• Subjects: Age; Ambulatory care; Codes; Cohort analysis; Comorbidity; Epidemiology; Health care policy; Health risks; Hospital costs; Infections; Length of stay; Mortality; Original; Original Article; Pacemakers; Patients; Personal health; Population; Rural areas; Surveillance; Transplants & implants; Vital statistics
• ISSN: 0899-823X; 1559-6834
• DOI: 10.1017/ice.2023.48

To establish the epidemiology of cardiac implantable electronic device (CIED) infections in Alberta, Canada, using validated administrative data. Retrospective, population-based cohort study. Alberta Health Services is a province-wide health system that services all of Alberta, Canada. Adult patients who underwent first-time CIED implantation or generator replacement in Alberta, Canada, between January 1, 2011, and December 31, 2019. CIED implant patients were identified from the Paceart database. Patients who developed an infection within 1 year of the index procedure were identified through validated administrative data (International Classification of Diseases, Tenth Revision in Canada). Demographic characteristics of patients were summarized. Logistic regression models were used to analyze device type, comorbidities, and demographics associated with infection rates and mortality. Among 27,830 CIED implants, there were 205 infections (0.74%). Having 2 or more comorbidities was associated with higher infection risk. Generator replacement procedures (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.34-0.84; P = .008), age increase of every 10 years (OR, 0.73; 95% CI, 0.66-0.82; P ≤ .001), and index procedure after 2014 were associated with decreased risk. Comparing the infected to uninfected groups, the hospitalization rates were 2.63 compared to 0.69, and the mortality rates were 10.73% compared to 3.49%, respectively (P < .001). There is a slightly lower overall rate of CIED infections Alberta, Canada compared to previously described epidemiology. Implants after 2014, and generator replacements showed a decreased burden of infection. Patients with younger age, and 2 or more comorbidities are at greatest risk of CIED infection. The burden of hospitalization and mortality is substantially higher in infected patients.