Topoisomerase mutations in trovafloxacin-resistant Staphylococcus aureus

A total of 201 Staphylococcus aureus isolates were surveyed for susceptibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resistant isolates, 89% were ciprofloxacin resistant and 6% were also trovafloxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resist...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 1998-08, Vol.42 (8), p.2122-2124
Main Authors: FITZGIBBON, J. E, JOHN, J. F, DELUCIA, J. L, DUBIN, D. T
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Ciprofloxacin - pharmacology
DNA Topoisomerase IV
DNA Topoisomerases, Type II - genetics
Drug Resistance, Microbial
Fluoroquinolones
Humans
Mechanisms of Resistance
Medical sciences
Microbial Sensitivity Tests
Mutation
Naphthyridines - pharmacology
Pharmacology. Drug treatments
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - enzymology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A total of 201 Staphylococcus aureus isolates were surveyed for susceptibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resistant isolates, 89% were ciprofloxacin resistant and 6% were also trovafloxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resistance mutations in DNA topoisomerase genes, including two mutations in the A subunit (encoded by grlA) of topoisomerase IV.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.42.8.2122