Neuronal Activity Changes the Number of Neurons That Are Synaptically Connected to OPCs

The timing and specificity of oligodendrocyte myelination during development, as well as remyelination after injury or immune attack, remain poorly understood. Recent work has shown that oligodendrocyte progenitors receive synapses from neurons, providing a potential mechanism for neuronal-glial com...

Full description

Saved in:
Bibliographic Details
Published in:eNeuro 2023-10, Vol.10 (10), p.ENEURO.0126-23.2023
Main Authors: Moura, Daniela, Parvathaneni, Alekhya, Sahagun, Atehsa, Noguchi, Hirofumi, Garcia, Jesse, Brennan, Emma, Brock, Robert, Tilton, Iris, Halladay, Lindsay, Pleasure, Samuel, Cocas, Laura
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Mice
Neurogenesis
Neuroglia
Neurons - physiology
New Research
Oligodendrocyte Precursor Cells
Oligodendroglia
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The timing and specificity of oligodendrocyte myelination during development, as well as remyelination after injury or immune attack, remain poorly understood. Recent work has shown that oligodendrocyte progenitors receive synapses from neurons, providing a potential mechanism for neuronal-glial communication. In this study, we investigated the importance of these neuroglial connections in myelination during development and during neuronal plasticity in the mouse hippocampus. We used chemogenetic tools and viral monosynaptic circuit tracing to analyze these connections and to examine oligodendrocyte progenitor cells (OPCs) proliferation, myelination, synapse formation, and neuronal-glial connectivity after increasing or decreasing neuronal activity levels We found that increasing neuronal activity led to greater OPC activation and proliferation. Modulation of neuronal activity also altered the organization of neuronal-glial connections: while it did not impact the total number of RabV-labeled neuronal inputs, or the number of RabV-labeled inhibitory neuronal (IN) inputs, it did alter the number of RabV-labeled excitatory neuron to OPC connections. Overall, our findings support the idea that neuronal activity plays a crucial role in regulating OPC proliferation and activation as well as the types of neuronal inputs to OPCs, indicating that neuronal activity is important for OPC circuit composition and function.
ISSN:2373-2822
2373-2822
DOI:10.1523/ENEURO.0126-23.2023