Xanthohumol ameliorates cardiac injury induced by sepsis in a mice model: role of toll-like receptor 4

Sepsis, a life-threatening condition arising from infection, often results in multi-organ failure, including cardiac dysfunction. This study investigated Xanthohumol, a natural compound, and its potential mechanism of action to enhance heart function following sepsis. A total of twenty-four adult ma...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medicine and life 2023-07, Vol.16 (7), p.1105-1110
Main Authors: Hadi, Sarah Mohammed Hussain, Majeed, Sahar, Ghafil, Fadhaa Abdulameer, Altoraihi, Kaswer, Hadi, Najah Rayish
Format: Article
Language:English
Subjects:
Abdomen
Albinism
Apoptosis
Cardiomyocytes
Creatinine
Cytokines
Heart
Infections
Ischemia
Kinases
Laparotomy
Mortality
Normal distribution
Original
Oxidative stress
Sepsis
Signal transduction
Statistical analysis
TLR4 protein
Toll-like receptors
Tumor necrosis factor-TNF
Variance analysis
Xanthohumol
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sepsis, a life-threatening condition arising from infection, often results in multi-organ failure, including cardiac dysfunction. This study investigated Xanthohumol, a natural compound, and its potential mechanism of action to enhance heart function following sepsis. A total of twenty-four adult male Swiss albino mice were allocated randomly to one of four equal groups (n=6): sham, CLP, vehicle Xanthohumol the same amount of DMSO injected IP 10 minutes before the CLP, and Xanthohumol group (0.4 mg/kg of Xanthohumol administered IP before the CLP process). Toll-like receptor 4, pro-inflammatory mediators, anti-inflammatory markers, oxidative stress indicators, apoptosis markers, and serum cardiac damage biomarkers were measured in the cardiac tissue using ELISA. Data with normal distribution were analyzed using t-test and ANOVA tests (p
ISSN:1844-3117
1844-122X
1844-3117
DOI:10.25122/jml-2023-0016