Advances and Applications of Brain Organoids

Understanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans. Over the past years, an em...

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Bibliographic Details
Published in:Neuroscience bulletin 2023-11, Vol.39 (11), p.1703-1716
Main Authors: Li, Yang, Zeng, Peng-Ming, Wu, Jian, Luo, Zhen-Ge
Format: Article
Language:English
Subjects:
Anatomy
Anesthesiology
Animals
Biomedical and Life Sciences
Biomedicine
Brain
Brain - pathology
Brain tumors
Development and progression
Disease Models, Animal
Human Physiology
Humans
Induced Pluripotent Stem Cells
Mice
Neurodegenerative Diseases - pathology
Neurology
Neurosciences
Organoids - pathology
Pain Medicine
Review
Stem cells
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Summary:Understanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans. Over the past years, an emerging model, the “brain organoid” integrated from human pluripotent stem cells, has been developed to mimic developmental processes of the human brain and disease-associated phenotypes to some extent, making it possible to better understand the complex structures and functions of the human brain. In this review, we summarize recent advances in brain organoid technologies and their applications in brain development and diseases, including neurodevelopmental, neurodegenerative, psychiatric diseases, and brain tumors. Finally, we also discuss current limitations and the potential of brain organoids.
ISSN:1673-7067
1995-8218
1995-8218
DOI:10.1007/s12264-023-01065-2