Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis

AbstractAlthough the past two decades have produced exciting discoveries in the genetics and pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy remains slow. This review summarizes the critical discoveries and outlines the advances in disease characterizati...

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Bibliographic Details
Published in:BMJ (Online) 2023-10, Vol.383, p.e075037-e075037
Main Authors: Ilieva, Hristelina, Vullaganti, Mithila, Kwan, Justin
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Aphasia
Atrophy
Behavior
Biomarkers
Clinical Review
Cognitive ability
Dementia
Diagnosis
Medical diagnosis
Medical prognosis
Motor neurone disease
Neurodegeneration
Neuropsychology
Pathology
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Summary:AbstractAlthough the past two decades have produced exciting discoveries in the genetics and pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy remains slow. This review summarizes the critical discoveries and outlines the advances in disease characterization, diagnosis, imaging, and biomarkers, along with the current status of approaches to ALS care and treatment. Additional knowledge of the factors driving disease progression and heterogeneity will hopefully soon transform the care for patients with ALS into an individualized, multi-prong approach able to prevent disease progression sufficiently to allow for a dignified life with limited disability.
ISSN:1756-1833
0959-8138
1756-1833
DOI:10.1136/bmj-2023-075037