Clinical Outcomes of Upfront Primary Tumor Resection in Synchronous Unresectable Metastatic Colorectal Cancer

The role of upfront primary tumor resection (PTR) in patients with unresectable metastatic colorectal cancer without severe symptoms remains controversial. We retrospectively analyzed the role of PTR in overall survival (OS) in this population. Among the 205 patients who enrolled, the PTR group (n =...

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Bibliographic Details
Published in:Cancers 2023-10, Vol.15 (20), p.5057
Main Authors: Shin, Ji Eun, An, Ho Jung, Shim, Byoung Yong, Kim, Hyunho, Park, Hyung Soon, Cho, Hyeon-Min, Kye, Bong-Hyeon, Yoo, Ri Na, Moon, Ji-Yeon, Kim, Sung Hwan, Lee, Jonghoon, Lee, Hyo Chun, Jung, Ji-Han, Lee, Kang-Moon, Lee, Ji Min
Format: Article
Language:English
Subjects:
Bevacizumab
Cancer
Cancer patients
Cancer therapies
Chemotherapy
Clinical outcomes
Colorectal cancer
Colorectal carcinoma
Medical prognosis
Metastases
Metastasis
Multivariate analysis
Oncology, Experimental
Patient outcomes
Patients
Surgery
Survival
Tumors
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Summary:The role of upfront primary tumor resection (PTR) in patients with unresectable metastatic colorectal cancer without severe symptoms remains controversial. We retrospectively analyzed the role of PTR in overall survival (OS) in this population. Among the 205 patients who enrolled, the PTR group (n = 42) showed better performance (p = 0.061), had higher frequencies of right-sided origin (p = 0.058), the T4 stage (p = 0.003), the M1a stage (p = 0.012), and
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15205057