Effect of Vitamin B12 Replacement Intervals on Clinical Symptoms and Laboratory Findings in Gastric Cancer Patients after Total Gastrectomy

The management of patients with vitamin B12 deficiency after total gastrectomy (TG) remains controversial. We aimed to evaluate the effect of vitamin B12 replacement intervals on the clinical characteristics in these patients. The data from patients who received vitamin B12 supplementation after TG...

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Bibliographic Details
Published in:Cancers 2023-10, Vol.15 (20), p.4938
Main Authors: Park, Sin Hye, Eom, Sang Soo, Lee, Hyewon, Eom, Bang Wool, Yoon, Hong Man, Kim, Young-Woo, Ryu, Keun Won
Format: Article
Language:English
Subjects:
Anemia
Cancer patients
Cancer therapies
Care and treatment
Chemotherapy
Dietary supplements
Gastrectomy
Gastric cancer
Gastrointestinal surgery
Glycosylated hemoglobin
Hemoglobin
Laboratories
Medical research
Medicine, Experimental
Patients
Stomach cancer
Urine
Variables
Vitamin B12
Vitamin deficiency
Vitamins
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Summary:The management of patients with vitamin B12 deficiency after total gastrectomy (TG) remains controversial. We aimed to evaluate the effect of vitamin B12 replacement intervals on the clinical characteristics in these patients. The data from patients who received vitamin B12 supplementation after TG between 2007 and 2018 at the National Cancer Center, Korea, were retrospectively evaluated. Vitamin B12 deficiency was defined as a serum vitamin B12 level of 3.8 mg/gCr. The patients were divided into a regular replacement group (patients received an intramuscular injection or oral medication regularly), and a lab-based replacement group (patients received vitamin B12 intermittently after checking the level). The symptoms and biochemical parameters were compared between these groups. The regular and lab-based replacement groups included 190 and 216 patients, respectively. The median vitamin B12 replacement intervals were 1 and 9 months, respectively (p < 0.001). After replacement, the regular replacement group had higher vitamin B12 levels than the lab-based replacement group (p < 0.001). However, the serum hemoglobin level showed no significant changes. After replacement, there was no significant difference in the proportion of the symptomatic patients between the groups. Replacing vitamin B12 with a lab-based protocol may be sufficient for TG patients.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15204938