The Role of ncRNAs in the Immune Dysregulation of Preeclampsia

The main complications causing practically 75% of all maternal deaths are severe bleeding, infections, and high blood pressure during pregnancy (preeclampsia (PE) and eclampsia). The usefulness of ncRNAs as clinical biomarkers has been explored in an extensive range of human diseases including pregn...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-10, Vol.24 (20), p.15215
Main Authors: Mora-Palazuelos, Carlos, Villegas-Mercado, Carlos Esteban, Avendaño-Félix, Mariana, Lizárraga-Verdugo, Erik, Romero-Quintana, José Geovanni, López-Gutiérrez, Jorge, Beltrán-Ontiveros, Saúl, Bermúdez, Mercedes
Format: Article
Language:English
Subjects:
B cells
Biosynthesis
Cytokines
Gene expression
Hypertension
Hypoxia
Immunology
International organizations
Kinases
Maternal mortality
MicroRNA
MicroRNAs
Mothers
Neutrophils
Pathogenesis
Pathophysiology
Patient outcomes
Placenta
Preeclampsia
Pregnancy
Proteins
Review
RNA polymerase
Tumor necrosis factor-TNF
Vascular endothelial growth factor
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Summary:The main complications causing practically 75% of all maternal deaths are severe bleeding, infections, and high blood pressure during pregnancy (preeclampsia (PE) and eclampsia). The usefulness of ncRNAs as clinical biomarkers has been explored in an extensive range of human diseases including pregnancy-related diseases such as PE. Immunological dysregulation show that the Th1/17:Th2/Treg ratio is “central and causal” to PE. However, there is evidence of the involvement of placenta-expressed miRNAs and lncRNAs in the immunological regulation of crucial processes of placenta development and function during pregnancy. Abnormal expression of these molecules is related to immune physiopathological processes that occur in PE. Therefore, this work aims to describe the importance of miRNAs and lncRNAs in immune dysregulation in PE. Interestingly, multiple ncRNAS are involved in the immune dysregulation of PE participating in type 1 immune response regulation, immune microenvironment regulation in placenta promoting inflammatory factors, trophoblast cell invasion in women with Early-Onset PE (EOPE), placental development, and angiogenesis, promotion of population of M1 and M2, proliferation, invasion, and migration of placental trophoblast cells, and promotion of invasion and autophagy through vias such as PI3K/AKT/mTOR, VEGF/VEGFR1, and TLR9/STAT3.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242015215