Reproductive Outcomes of Women with Turner Syndrome Undergoing Oocyte Vitrification: A Retrospective Multicenter Cohort Study

Background: Turner syndrome (TS) is accompanied with premature ovarian insufficiency. Oocyte vitrification is an established method to preserve fertility. However, data on the oocyte yield in women with TS who vitrify their oocytes and the return rate to utilize the oocytes are scarce. Methods: Retr...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-10, Vol.12 (20), p.6502
Main Authors: Nadesapillai, Sapthami, Mol, Femke, Broer, Simone L, Stevens Brentjens, Linda B. P. M, Verhoeven, Marieke O, Heida, Karst Y, Goddijn, Mariëtte, van Golde, Ron J. T, Bos, Annelies M. E, van der Coelen, Sanne, Peek, Ronald, Braat, Didi D. M, van der Velden, Janielle A. E. M, Fleischer, Kathrin
Format: Article
Language:English
Subjects:
Age
Analysis
Care and treatment
Chromosomes
Clinical medicine
Cohort analysis
Coronary vessels
Drug dosages
Fertility
Genetic disorders
Human reproductive technology
Infertility
Infertility, Female
Lymphocytes
Medical records
Medical research
Medicine, Experimental
Methods
Normal distribution
Ovaries
Patient outcomes
Pregnancy
Questionnaires
Statistical analysis
Turner syndrome
Women
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Summary:Background: Turner syndrome (TS) is accompanied with premature ovarian insufficiency. Oocyte vitrification is an established method to preserve fertility. However, data on the oocyte yield in women with TS who vitrify their oocytes and the return rate to utilize the oocytes are scarce. Methods: Retrospective multicenter cohort study. Data was collected from medical records of women with TS who started oocyte vitrification between 2010 and 2021. Results: Thirty-three women were included. The median cumulative number of vitrified oocytes was 20 per woman. Complications occurred in 4% of the cycles. Significant correlations were found between the cumulative number of vitrified oocytes and AMH (r = 0.54 and p < 0.01), AFC (r = 0.49 and p < 0.01), percentage of 46,XX cells (r = 0.49 and p < 0.01), and FSH (r = −0.65 and p < 0.01). Spontaneous (n = 8) and IVF (n = 2) pregnancies occurred in 10 women ± three years after vitrification. So far, none of the women have returned to utilize their vitrified oocytes. Conclusions: Oocyte vitrification is a feasible fertility preservation option for women with TS, particularly in those with 46,XX cell lines or sufficient ovarian reserve. Multiple stimulation cycles are recommended to reach an adequate number of vitrified oocytes for pregnancy. It is too early to draw conclusions about the utilization of vitrified oocytes in women with TS.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12206502