Smoking and Diabetes Attenuate Number of CD34+ Haematopoietic Stem Cells in Peripheral Blood of Patients with Advanced Peripheral Artery Disease

Peripheral artery disease (PAD) is a globally prevalent problem with limited treatment options, leaving up to a fifth of patients remediless. The emergence of new studies on cell therapy in recent years offers a new promising option for their treatment. Our aim was to explore how the number of CD34+...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-10, Vol.24 (20), p.15346
Main Authors: Sernek, Barbara, Kamnikar, Rok, Sebestjen, Miran, Boc, Anja, Boc, Vinko
Format: Article
Language:English
Subjects:
Age
Angiogenesis
Atherosclerosis
Bioavailability
Bone marrow
Cardiac patients
Cardiovascular disease
Coronary vessels
Diabetes
DNA methylation
Ethylenediaminetetraacetic acid
Health aspects
Hematopoietic stem cells
Intermittent claudication
Ischemia
Nitric oxide
Oxidative stress
Patients
Prevention
Risk factors
Smoking
Stem cells
Vein & artery diseases
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Summary:Peripheral artery disease (PAD) is a globally prevalent problem with limited treatment options, leaving up to a fifth of patients remediless. The emergence of new studies on cell therapy in recent years offers a new promising option for their treatment. Our aim was to explore how the number of CD34+ hematopoietic cells in the peripheral blood of PAD patients is associated with patients’ functional as well as atherogenic factors. We selected 30 patients with advanced PAD, recorded their performance in a walking test in standard conditions and sampled their blood for further analysis with an emphasis on CD34+ cell selection and counting. No correlation of the CD34+ cell number was confirmed with any of the observed laboratory parameters. There was an association between the claudication distance and the number of CD34+ cells (r = −0.403, p = 0.046). The number of CD34+ cells differed between patients with and without type II diabetes (p = 0.071) and between active smokers, past smokers, and non-smokers (p = 0.035; p = 0.068, p = 0.051, respectively), with both smoking and presence of diabetes type II having a negative effect on the number of CD34+ cells. Our study demonstrated a dependence of the CD34+ cell number on the patient’s characteristics.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242015346