Influence of Moisturizers on Skin Microcirculation: An Assessment Study Using Laser Speckle Contrast Imaging

• Published in: Journal of personalized medicine 2023-10, Vol.13 (10), p.1507
• Main Authors: De Decker, Ignace, Klotz, Tanja, Vu, Peter, Hoeksema, Henk, De Mey, Kimberly, Beeckman, Anse, Vermeulen, Bob, Speeckaert, Marijn, Blondeel, Phillip, Wagstaff, Marcus, Monstrey, Stan, Claes, Karel E. Y
• Format: Article
• Language: English
• Subjects: Blood flow; Blood pressure; Collagen; Cytokines; Erythema; Fibroblasts; Hydration; Lasers; Neurotrophin 1; Neurotrophin 3; Occlusion; Precision medicine; Scars; Silicones; Skin; Transforming growth factor-b1
• ISSN: 2075-4426; 2075-4426
• DOI: 10.3390/jpm13101507

Non-invasive scar management typically involves pressure therapy, hydration with silicones or moisturizers, and UV protection. Moisture loss from scars can lead to hypertrophic scar formation. Pressure therapy reduces blood flow, fibroblast activity, and transforming growth factor beta 1 (TGF-β1) release. This study examined various moisturizers and liquid silicone gel’s impact on microcirculation. 40 volunteers participated in a study where superficial abrasions were created to induce trans epidermal water loss (TEWL). Five moisturizers (TEDRA®, TEDRA® NT1, TEDRA® NT3, Alhydran®, Lipikar®) and BAP Scar Care® silicone gel were tested. TEWL, hydration, and blood flow were measured up to 4 h post-application. Results showed that silicone had the least impact on occlusion and hydration. Alhydran® reduced blood flow the most, while Lipikar® increased it the most. TEDRA® NT1 had reduced flow compared to TEDRA® and TEDRA® NT3. All TEDRA® products exhibited high hydration, and all but silicone showed good occlusion. Moisturizers influenced skin microcirculation, with some causing decrease, while others increased flow. However, the clinical impact on scarring remains unclear compared to the evident effects of hydration and occlusion. More research is necessary to study moisturizers alone and with pressure therapy on scars, along with potential adverse effects of increased microcirculation on scars.