Guidelines for the safe administration of inhaled nitric oxide

Inhaled nitric oxide (NO) is a selective pulmonary vasodilator, potentially useful in the treatment of pulmonary hypertension and ventilation-perfusion mismatch. High doses of inhaled NO and its oxidative product nitrogen dioxide (NO2) may cause acute lung injury. Using a standard infant ventilator,...

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Bibliographic Details
Published in:Archives of disease in childhood 1994-01, Vol.70 (1), p.F47-F49
Main Authors: Miller, O I, Celermajer, D S, Deanfield, J E, Macrae, D J
Format: Article
Language:English
Subjects:
Administration, Inhalation
Biological and medical sciences
Drug Administration Schedule
Humans
Hypertension
Hypertension, Pulmonary - drug therapy
Infant
Infants
Medical sciences
Models, Biological
Nitric oxide
Nitric Oxide - administration & dosage
Nitric Oxide - adverse effects
Nitric Oxide - metabolism
Nitrogen dioxide
Nitrogen Dioxide - metabolism
Pneumology
Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
Respiration, Artificial - standards
Ventilation
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Summary:Inhaled nitric oxide (NO) is a selective pulmonary vasodilator, potentially useful in the treatment of pulmonary hypertension and ventilation-perfusion mismatch. High doses of inhaled NO and its oxidative product nitrogen dioxide (NO2) may cause acute lung injury. Using a standard infant ventilator, ventilator circuit and test lung, an administration and monitoring strategy has been defined for inhaled NO and these observations validated in eight ventilated infants. In 90% oxygen, doses of inhaled NO > or = 80 parts per million may result in toxic NO2 concentrations.
ISSN:1359-2998
0003-9888
1468-2052
1468-2044
DOI:10.1136/fn.70.1.F47