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Guidelines for the safe administration of inhaled nitric oxide
Inhaled nitric oxide (NO) is a selective pulmonary vasodilator, potentially useful in the treatment of pulmonary hypertension and ventilation-perfusion mismatch. High doses of inhaled NO and its oxidative product nitrogen dioxide (NO2) may cause acute lung injury. Using a standard infant ventilator,...
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| Published in: | Archives of disease in childhood 1994-01, Vol.70 (1), p.F47-F49 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-b502t-e68f999b4b4499314c0dc9485cacb21b5ebb1b404b62232eefa22b9a1c4741883 |
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| cites | cdi_FETCH-LOGICAL-b502t-e68f999b4b4499314c0dc9485cacb21b5ebb1b404b62232eefa22b9a1c4741883 |
| container_end_page | F49 |
| container_issue | 1 |
| container_start_page | F47 |
| container_title | Archives of disease in childhood |
| container_volume | 70 |
| creator | Miller, O I Celermajer, D S Deanfield, J E Macrae, D J |
| description | Inhaled nitric oxide (NO) is a selective pulmonary vasodilator, potentially useful in the treatment of pulmonary hypertension and ventilation-perfusion mismatch. High doses of inhaled NO and its oxidative product nitrogen dioxide (NO2) may cause acute lung injury. Using a standard infant ventilator, ventilator circuit and test lung, an administration and monitoring strategy has been defined for inhaled NO and these observations validated in eight ventilated infants. In 90% oxygen, doses of inhaled NO > or = 80 parts per million may result in toxic NO2 concentrations. |
| doi_str_mv | 10.1136/fn.70.1.F47 |
| format | article |
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High doses of inhaled NO and its oxidative product nitrogen dioxide (NO2) may cause acute lung injury. Using a standard infant ventilator, ventilator circuit and test lung, an administration and monitoring strategy has been defined for inhaled NO and these observations validated in eight ventilated infants. In 90% oxygen, doses of inhaled NO > or = 80 parts per million may result in toxic NO2 concentrations.</description><identifier>ISSN: 1359-2998</identifier><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2052</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/fn.70.1.F47</identifier><identifier>PMID: 8117128</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Administration, Inhalation ; Biological and medical sciences ; Drug Administration Schedule ; Humans ; Hypertension ; Hypertension, Pulmonary - drug therapy ; Infant ; Infants ; Medical sciences ; Models, Biological ; Nitric oxide ; Nitric Oxide - administration & dosage ; Nitric Oxide - adverse effects ; Nitric Oxide - metabolism ; Nitrogen dioxide ; Nitrogen Dioxide - metabolism ; Pneumology ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Respiration, Artificial - standards ; Ventilation</subject><ispartof>Archives of disease in childhood, 1994-01, Vol.70 (1), p.F47-F49</ispartof><rights>1994 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Jan 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b502t-e68f999b4b4499314c0dc9485cacb21b5ebb1b404b62232eefa22b9a1c4741883</citedby><cites>FETCH-LOGICAL-b502t-e68f999b4b4499314c0dc9485cacb21b5ebb1b404b62232eefa22b9a1c4741883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1060988/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1060988/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3925732$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8117128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, O I</creatorcontrib><creatorcontrib>Celermajer, D S</creatorcontrib><creatorcontrib>Deanfield, J E</creatorcontrib><creatorcontrib>Macrae, D J</creatorcontrib><title>Guidelines for the safe administration of inhaled nitric oxide</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description>Inhaled nitric oxide (NO) is a selective pulmonary vasodilator, potentially useful in the treatment of pulmonary hypertension and ventilation-perfusion mismatch. High doses of inhaled NO and its oxidative product nitrogen dioxide (NO2) may cause acute lung injury. Using a standard infant ventilator, ventilator circuit and test lung, an administration and monitoring strategy has been defined for inhaled NO and these observations validated in eight ventilated infants. In 90% oxygen, doses of inhaled NO > or = 80 parts per million may result in toxic NO2 concentrations.</description><subject>Administration, Inhalation</subject><subject>Biological and medical sciences</subject><subject>Drug Administration Schedule</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pulmonary - drug therapy</subject><subject>Infant</subject><subject>Infants</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - administration & dosage</subject><subject>Nitric Oxide - adverse effects</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitrogen dioxide</subject><subject>Nitrogen Dioxide - metabolism</subject><subject>Pneumology</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Respiration, Artificial - standards</subject><subject>Ventilation</subject><issn>1359-2998</issn><issn>0003-9888</issn><issn>1468-2052</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNp9kEFvEzEUhC1EVULhxBlpJSouaIOf7V2vL5FQStNKAQ5AOVq21yYOGzvYG9T-e9wmisqFk0eaz_NGg9ArwFMA2r53YcqLnF4y_gRNgLVdTXBDnhZNG1ETIbpn6HnOa4wxcM5P0WkHwIF0EzRb7HxvBx9srlxM1biyVVbOVqrf-ODzmNToY6iiq3xYqcH2VfBj8qaKt-XjC3Ti1JDty8N7hr5ffvw2v6qXXxbX8w_LWjeYjLVtOyeE0EwzJgQFZnBvBOsao4wmoBurNWiGmW4JocRapwjRQoFhnEHX0TM02-dud3pje2NDKTbIbfIble5kVF7-6wS_kj_jHwm4xeIh4M0hIMXfO5tHuY67FEpnWSbBmAIwKNS7PWVSzDlZd7wAWN5vLV2QvEhZti7068eljuxh3OKfH3yVjRpcUsH4fMSoIA2npGD1Hitr29ujrdIv2XLKG_n5Zi7J4uLHp683VN6ffbvn9Wb9335_Aejsoho</recordid><startdate>199401</startdate><enddate>199401</enddate><creator>Miller, O I</creator><creator>Celermajer, D S</creator><creator>Deanfield, J E</creator><creator>Macrae, D J</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>199401</creationdate><title>Guidelines for the safe administration of inhaled nitric oxide</title><author>Miller, O I ; Celermajer, D S ; Deanfield, J E ; Macrae, D J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b502t-e68f999b4b4499314c0dc9485cacb21b5ebb1b404b62232eefa22b9a1c4741883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Administration, Inhalation</topic><topic>Biological and medical sciences</topic><topic>Drug Administration Schedule</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension, Pulmonary - drug therapy</topic><topic>Infant</topic><topic>Infants</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - administration & dosage</topic><topic>Nitric Oxide - adverse effects</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitrogen dioxide</topic><topic>Nitrogen Dioxide - metabolism</topic><topic>Pneumology</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Respiration, Artificial - standards</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, O I</creatorcontrib><creatorcontrib>Celermajer, D S</creatorcontrib><creatorcontrib>Deanfield, J E</creatorcontrib><creatorcontrib>Macrae, D J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, O I</au><au>Celermajer, D S</au><au>Deanfield, J E</au><au>Macrae, D J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Guidelines for the safe administration of inhaled nitric oxide</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><date>1994-01</date><risdate>1994</risdate><volume>70</volume><issue>1</issue><spage>F47</spage><epage>F49</epage><pages>F47-F49</pages><issn>1359-2998</issn><issn>0003-9888</issn><eissn>1468-2052</eissn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>Inhaled nitric oxide (NO) is a selective pulmonary vasodilator, potentially useful in the treatment of pulmonary hypertension and ventilation-perfusion mismatch. High doses of inhaled NO and its oxidative product nitrogen dioxide (NO2) may cause acute lung injury. Using a standard infant ventilator, ventilator circuit and test lung, an administration and monitoring strategy has been defined for inhaled NO and these observations validated in eight ventilated infants. In 90% oxygen, doses of inhaled NO > or = 80 parts per million may result in toxic NO2 concentrations.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>8117128</pmid><doi>10.1136/fn.70.1.F47</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1359-2998 |
| ispartof | Archives of disease in childhood, 1994-01, Vol.70 (1), p.F47-F49 |
| issn | 1359-2998 0003-9888 1468-2052 1468-2044 |
| language | eng |
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| source | Social Science Premium Collection; PubMed Central; Education Collection |
| subjects | Administration, Inhalation Biological and medical sciences Drug Administration Schedule Humans Hypertension Hypertension, Pulmonary - drug therapy Infant Infants Medical sciences Models, Biological Nitric oxide Nitric Oxide - administration & dosage Nitric Oxide - adverse effects Nitric Oxide - metabolism Nitrogen dioxide Nitrogen Dioxide - metabolism Pneumology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Respiration, Artificial - standards Ventilation |
| title | Guidelines for the safe administration of inhaled nitric oxide |
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