Erythromycin in neonatal postoperative intestinal dysmotility

The motilin agonist erythromycin was used successfully in four infants receiving prolonged parenteral nutrition for severe intestinal dysmotility after gastrointestinal surgery. In a further child with a neuropathic intestinal pseudo-obstruction erythromycin induced a striking small intestinal manom...

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Bibliographic Details
Published in:Archives of disease in childhood. Fetal and neonatal edition 1994-09, Vol.71 (2), p.F128-F129
Main Authors: Simkiss, D E, Adams, I P, Myrdal, U, Booth, I W
Format: Article
Language:English
Subjects:
Erythromycin - therapeutic use
Gastrointestinal Motility - drug effects
Humans
Infant, Newborn
Infant, Premature
Intestinal Diseases - drug therapy
Intestine, Small - physiopathology
Jejunum - abnormalities
Manometry
Original
Parenteral nutrition
Postoperative Complications - drug therapy
Postoperative Complications - physiopathology
Stomach - abnormalities
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Description
Summary:The motilin agonist erythromycin was used successfully in four infants receiving prolonged parenteral nutrition for severe intestinal dysmotility after gastrointestinal surgery. In a further child with a neuropathic intestinal pseudo-obstruction erythromycin induced a striking small intestinal manometric response, but was without effect in a child with an intestinal myopathy.
ISSN:1359-2998
1468-2052
DOI:10.1136/fn.71.2.F128