Striatal hypoactivation during monetary loss anticipation in individuals with substance use disorders in a heterogenous urban American Indian sample

Research suggests that disproportionate exposure to risk factors places American Indian (AI) peoples at higher risk for substance use disorders (SUD). Although SUD is linked to striatal prioritization of drug rewards over other appetitive stimuli, there are gaps in the literature related to the inve...

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Bibliographic Details
Published in:Drug and alcohol dependence 2023-05, Vol.246, p.109852-109852, Article 109852
Main Authors: Wilhelm, Ricardo A., Spechler, Philip A., Demuth, Mara J., Gonzalez, Miigis, Kemp, Christopher, Walls, Melissa, Aupperle, Robin L., Paulus, Martin P., Stewart, Jennifer L., White, Evan J.
Format: Article
Language:English
Subjects:
American Indian or Alaska Native - psychology
American Indians
Anticipation, Psychological - physiology
Anticipatory reward processing
Corpus Striatum - diagnostic imaging
Corpus Striatum - physiopathology
Economic Factors
Humans
Income
Magnetic Resonance Imaging
Motivation - physiology
Nucleus Accumbens - diagnostic imaging
Nucleus Accumbens - physiopathology
Reward
Risk Factors
Substance use disorder
Substance-Related Disorders - diagnostic imaging
Substance-Related Disorders - economics
Substance-Related Disorders - ethnology
Substance-Related Disorders - psychology
Urban Population
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Summary:Research suggests that disproportionate exposure to risk factors places American Indian (AI) peoples at higher risk for substance use disorders (SUD). Although SUD is linked to striatal prioritization of drug rewards over other appetitive stimuli, there are gaps in the literature related to the investigation of aversive valuation processing, and inclusion of AI samples. To address these gaps, this study compared striatal anticipatory gain and loss processing between AI-identified with SUD (SUD+; n = 52) and without SUD (SUD-; n = 35) groups from the Tulsa 1000 study who completed a monetary incentive delay (MID) task during functional magnetic resonance imaging. Results indicated that striatal activations in the nucleus accumbens (NAcc), caudate, and putamen were greatest for anticipating gains (ps 
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2023.109852