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Comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study

Abstract The unique properties of nickel oxide nanoparticles distinguish it from classical nickel compounds, increasing its use in agriculture, industry, and many industrial areas. The aim of this study is to investigate the possible toxicity of nickel oxide and nickel oxide nanoparticles in the liv...

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Bibliographic Details
Published in:Toxicology research (Cambridge) 2023-10, Vol.12 (5), p.741-750
Main Authors: Adiguzel, Caglar, Karaboduk, Hatice, Apaydin, Fatma Gokce, Kalender, Suna, Kalender, Yusuf
Format: Article
Language:English
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Summary:Abstract The unique properties of nickel oxide nanoparticles distinguish it from classical nickel compounds, increasing its use in agriculture, industry, and many industrial areas. The aim of this study is to investigate the possible toxicity of nickel oxide and nickel oxide nanoparticles in the liver. For this purpose, Wistar rats were given nickel oxide and nickel oxide nanoparticles orally, intraperitoneally, and intravenously for 21 days. Liver organ weight, biochemical and hematological parameters, oxidative stress (malondialdehyde, catalase, superoxide dismutase, glutathione peroxidase, and glutathione S transferase), acetylcholinesterase activities, inflammation levels, apoptotic markers, and histopathological changes were evaluated comparatively. When the data obtained were examined in general, it was observed that nickel oxide nanoparticles caused more hepatotoxicity in liver tissue than nickel oxide in terms of oxidative stress parameters, apoptotic markers, inflammation indicators, and other parameters examined. The results suggest that toxicity induced by both nickel oxide and nickel oxide nanoparticles plays an important role in hepatocyte apoptosis.
ISSN:2045-4538
2045-452X
2045-4538
DOI:10.1093/toxres/tfad062